Free Fatty Acid-Induced Cellular Stress Response and Protective Role of Palmitoleate

PK Sahoo - 2023 - search.proquest.com
Maternal obesity has emerged as a significant health challenge in the 21 st century and has
been shown to influence the health of the fetus in utero and later in life. The prevalence of …

Palmitate induces integrated stress response and lipoapoptosis in trophoblasts

PK Sahoo, C Krishnamoorthy, JR Wood… - Cell Death & …, 2024 - nature.com
Maternal obesity increases the risk of childhood obesity and programs the offspring to
develop metabolic syndrome later in their life. Palmitate is the predominant saturated free …

Saturated Free Fatty Acids Induce Trophoblast Lipoapoptosis

SK Natarajan, T Bruett, E Muthukrishnan… - The FASEB …, 2017 - Wiley Online Library
Obesity during pregnancy increases the risk for maternal complications like gestational
diabetes, preeclampsia, and maternal inflammation. Maternal obesity also increases the risk …

Saturated free fatty acids induce placental trophoblast lipoapoptosis

SK Natarajan, T Bruett, PG Muthuraj, PK Sahoo… - PLoS …, 2021 - journals.plos.org
Introduction Obesity during pregnancy increases the risk for maternal complications like
gestational diabetes, preeclampsia, and maternal inflammation. Maternal obesity also …

[PDF][PDF] Oleate attenuates palmitate-induced endoplasmic reticulum stress and apoptosis in placental trophoblasts

BN Colvin, MS Longtine, B Chen, ML Costa… - …, 2017 - repositorio.unicamp.br
Pre-pregnancy body mass index determines pregnancy outcome (Nelson et al. 2010, Flegal
et al. 2012), and more than half of pregnant women in the United States are overweight or …

Oleate protects macrophages from palmitate-induced apoptosis through the downregulation of CD36 expression

DH Kim, YM Cho, KH Lee, SW Jeong… - … and biophysical research …, 2017 - Elsevier
In obese patients, free fatty acids ectopically accumulated in non-adipose tissues cause cell
death. Saturated fatty acids are more deleterious to non-adipose cells, and supplementation …

Preimplantation exposure of mouse embryos to palmitic acid results in fetal growth restriction followed by catch-up growth in the offspring

ES Jungheim, ED Louden, MMY Chi… - Biology of …, 2011 - academic.oup.com
Free fatty acids (FFAs) are energy substrates for many cell types, but in excess, some FFAs
can accumulate in nonadipose cells, inducing apoptosis. Also known as lipotoxicity, this …

Docosahexaenoic acid antagonizes the boosting effect of palmitic acid on LPS inflammatory signaling by inhibiting gene transcription and ceramide synthesis

J Jin, Z Lu, Y Li, LA Cowart, MF Lopes-Virella… - PloS one, 2018 - journals.plos.org
It is well known that saturated fatty acids (SFAs) and unsaturated fatty acid, in particular
omega-3 polyunsaturated fatty acids (n-3 PUFAs), have different effects on inflammatory …

[HTML][HTML] Palmitate activates the NF-κB transcription factor and induces IL-6 and TNFα expression in 3T3-L1 adipocytes

KM Ajuwon, ME Spurlock - The Journal of nutrition, 2005 - Elsevier
Fatty acids and their metabolites regulate gene expression and immunological pathways.
Furthermore, obese individuals frequently have increased circulating fatty acid …

[HTML][HTML] Palmitic acid induces inflammatory cytokines and regulates tRNA-derived stress-induced RNAs in human trophoblasts

C Yang, G An, J Song, G Song, W Lim - Journal of Animal Reproduction …, 2022 - e-jarb.org
High levels of proinflammatory cytokines have been observed in obese pregnancies.
Obesity during pregnancy may increase the risk of various pregnancyrelated complications …