Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice
Background RNA-directed regulation of epigenetic processes has recently emerged as an
important feature of mammalian differentiation and development. Perturbation of this …
important feature of mammalian differentiation and development. Perturbation of this …
[HTML][HTML] Co-expression network modeling identifies key long non-coding RNA and mRNA modules in altering molecular phenotype to develop stress-induced …
Long non-coding RNAs (lncRNAs) have recently emerged as one of the critical epigenetic
controllers, which participate in several biological functions by regulating gene transcription …
controllers, which participate in several biological functions by regulating gene transcription …
Regulation of impulsive and aggressive behaviours by a novel lncRNA
B Labonté, K Abdallah, G Maussion, V Yerko… - Molecular …, 2021 - nature.com
High impulsive and aggressive traits associate with poor behavioural self-control. Despite
their importance in predicting behavioural negative outcomes including suicide, the …
their importance in predicting behavioural negative outcomes including suicide, the …
The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing
G Barry, JA Briggs, DP Vanichkina, EM Poth… - Molecular …, 2014 - nature.com
Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning.
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …
[HTML][HTML] Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders
PA Spadaro, TW Bredy - Frontiers in genetics, 2012 - frontiersin.org
Non-coding RNAs (ncRNAs) have emerged as critical regulators of transcription, epigenetic
processes, and gene silencing, which make them ideal candidates for insight into molecular …
processes, and gene silencing, which make them ideal candidates for insight into molecular …
[HTML][HTML] Intersectional analysis of chronic mild stress-induced lncRNA-mRNA interaction networks in rat hippocampus reveals potential anti-depression/anxiety drug …
W Liao, Y Liu, H Huang, H Xie, W Gong, D Liu… - Neurobiology of …, 2021 - Elsevier
Despite studies providing insight into the neurobiology of chronic stress, depression and
anxiety, long noncoding RNA (lncRNA)-mediated mechanisms underlying the common and …
anxiety, long noncoding RNA (lncRNA)-mediated mechanisms underlying the common and …
[HTML][HTML] The Long Non-Coding RNA GOMAFU in Schizophrenia: Function, Disease Risk, and Beyond
PM Zakutansky, Y Feng - Cells, 2022 - mdpi.com
Neuropsychiatric diseases are among the most common brain developmental disorders,
represented by schizophrenia (SZ). The complex multifactorial etiology of SZ remains poorly …
represented by schizophrenia (SZ). The complex multifactorial etiology of SZ remains poorly …
Long noncoding RNA-associated transcriptomic changes in resiliency or susceptibility to depression and response to antidepressant treatment
Background Recent emergence of long noncoding RNAs in regulating gene expression and
thereby modulating physiological functions in brain has manifested their possible role in …
thereby modulating physiological functions in brain has manifested their possible role in …
[HTML][HTML] Psychiatric disorders and lncRNAs: a synaptic match
Psychiatric disorders represent a heterogeneous class of multifactorial mental diseases
whose origin entails a pathogenic integration of genetic and environmental influences …
whose origin entails a pathogenic integration of genetic and environmental influences …
Integrating the roles of long and small non-coding RNA in brain function and disease
G Barry - Molecular psychiatry, 2014 - nature.com
Regulatory RNA is emerging as the major architect of cognitive evolution and innovation in
the mammalian brain. While the protein machinery has remained largely constant …
the mammalian brain. While the protein machinery has remained largely constant …