Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice

PA Spadaro, CR Flavell, J Widagdo, VS Ratnu… - Biological …, 2015 - Elsevier
Background RNA-directed regulation of epigenetic processes has recently emerged as an
important feature of mammalian differentiation and development. Perturbation of this …

[HTML][HTML] Co-expression network modeling identifies key long non-coding RNA and mRNA modules in altering molecular phenotype to develop stress-induced …

Q Wang, B Roy, Y Dwivedi - Translational Psychiatry, 2019 - nature.com
Long non-coding RNAs (lncRNAs) have recently emerged as one of the critical epigenetic
controllers, which participate in several biological functions by regulating gene transcription …

Regulation of impulsive and aggressive behaviours by a novel lncRNA

B Labonté, K Abdallah, G Maussion, V Yerko… - Molecular …, 2021 - nature.com
High impulsive and aggressive traits associate with poor behavioural self-control. Despite
their importance in predicting behavioural negative outcomes including suicide, the …

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing

G Barry, JA Briggs, DP Vanichkina, EM Poth… - Molecular …, 2014 - nature.com
Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning.
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …

[HTML][HTML] Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders

PA Spadaro, TW Bredy - Frontiers in genetics, 2012 - frontiersin.org
Non-coding RNAs (ncRNAs) have emerged as critical regulators of transcription, epigenetic
processes, and gene silencing, which make them ideal candidates for insight into molecular …

[HTML][HTML] Intersectional analysis of chronic mild stress-induced lncRNA-mRNA interaction networks in rat hippocampus reveals potential anti-depression/anxiety drug …

W Liao, Y Liu, H Huang, H Xie, W Gong, D Liu… - Neurobiology of …, 2021 - Elsevier
Despite studies providing insight into the neurobiology of chronic stress, depression and
anxiety, long noncoding RNA (lncRNA)-mediated mechanisms underlying the common and …

[HTML][HTML] The Long Non-Coding RNA GOMAFU in Schizophrenia: Function, Disease Risk, and Beyond

PM Zakutansky, Y Feng - Cells, 2022 - mdpi.com
Neuropsychiatric diseases are among the most common brain developmental disorders,
represented by schizophrenia (SZ). The complex multifactorial etiology of SZ remains poorly …

Long noncoding RNA-associated transcriptomic changes in resiliency or susceptibility to depression and response to antidepressant treatment

B Roy, Q Wang, Y Dwivedi - International Journal of …, 2018 - academic.oup.com
Background Recent emergence of long noncoding RNAs in regulating gene expression and
thereby modulating physiological functions in brain has manifested their possible role in …

[HTML][HTML] Psychiatric disorders and lncRNAs: a synaptic match

F Rusconi, E Battaglioli, M Venturin - International Journal of Molecular …, 2020 - mdpi.com
Psychiatric disorders represent a heterogeneous class of multifactorial mental diseases
whose origin entails a pathogenic integration of genetic and environmental influences …

Integrating the roles of long and small non-coding RNA in brain function and disease

G Barry - Molecular psychiatry, 2014 - nature.com
Regulatory RNA is emerging as the major architect of cognitive evolution and innovation in
the mammalian brain. While the protein machinery has remained largely constant …