Among the most potent carcinogens in tobacco are the tobacco-specific nitrosamines
(TSNAs), with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) being the most potent …

Tobacco specific nitrosamines (TSNAs) are among the most potent carcinogens found in
cigarettes and smokeless tobacco products. Decreases in TSNA detoxification, particularly 4 …

(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is reduced to its main metabolite, 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in a reaction that is both stereoselective …

(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is an important metabolite of the tobacco-
specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Using the chiral …

The tobacco-specific nitrosamines N′-nitrosonornicotine (NNN) and N′-nitrosoanatabine
(NAT) are found in substantial quantities in unburned tobacco. Although this has been …

Background: The most abundant and potent carcinogenic tobacco-specific nitrosamine in
tobacco and tobacco smoke is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). In …

(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen, is
believed to be important as a causative agent for lung cancer in smokers. NNK is extensively …

Objective To study the potential association between UDP-glucuronosyltransferase (UGT)
2B10 genotypes and [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol] NNAL-N …

The metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) was examined in the patas monkey, in order to provide further information …

(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a major metabolite of the tobacco-
specific lung carcino-gen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). NNAL has …