The concept of “stress” is often associated with unpleasant feelings, even though it is the
major trigger of the evolutionary processes. The refined system responsible for the …

Rationale The corticotropin-releasing hormone (CRH) system is a key mediator of stress-
induced responses in alcohol-seeking behavior. Recent research has identified the central …

The ability of many drugs of abuse, including cocaine, to mediate reinforcement and drug-
seeking behaviors is in part mediated by the corticotropin-releasing hormone (CRH) system …

Corticotropin-releasing hormone (CRH) and its receptor, CRH receptor-1 (CRHR1), have a
key role in alcoholism. Especially, post-dependent and stress-induced alcohol intake involve …

Corticotropin‐releasing hormone 1 receptors (CRH‐R1) mediate increased behavioral
sensitivity to stress and excessive alcohol self‐administration following a history of …

Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are often comorbid.
Few treatments exist to reduce comorbid PTSD/AUD. Elucidating the mechanisms …

Variations in the corticotropin-releasing hormone receptor 1 (CRHR1) gene have been
found to interact with stress in modulating excessive alcohol consumption. However, the …

To investigate the role of the corticotropin releasing hormone receptor 1 (CRHR1) in
patterns of human alcohol drinking and its potential contribution to alcohol dependence, we …

The ability of stress to trigger cocaine seeking in humans and rodents is variable and is
determined by the amount and pattern of prior drug use. This study examined the role of a …

Background and Purpose Dopamine and corticotrophin‐releasing hormone (CRH; also
known as corticotrophin‐releasing factor) are key neurotransmitters in the interaction …