Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

Abstract α-Synuclein (α-syn), a small protein that has the intrinsic propensity to aggregate, is
implicated in several neurodegenerative diseases including Parkinson's disease (PD) …

Aims The aim of this study was to test the hypothesis that different conformations of
misfolded α‐synuclein (α‐syn) are present in Parkinson's disease (PD) brain. Methods …

Synucleinopathies including Parkinson's disease, dementia with Lewy bodies and multiple
system atrophy are characterized by the abnormal accumulation and propagation of α …

The α-synuclein protein has been strongly correlated with Parkinson's disease (PD) and is a
major component of the hallmark Lewy body aggregates associated with PD. Two different …

In Parkinson's disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates
form a myriad of conformational and truncational variants. Most antibodies used to detect …

Sensitive detection of α-synuclein (α-syn) pathology is important in the diagnosis of
disorders like Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy …

The aggregation of alpha-synuclein (α-SYN) follows a cascade of oligomeric, prefibrillar and
fibrillar forms, culminating in the formation of Lewy Bodies (LB), the pathological hallmarks of …

Summary α-Synuclein (α-syn) has been shown to form various conformational fibrils
associated with different synucleinopathies. But whether the conformation of α-syn fibrils …

Oligomeric forms of alpha-synuclein are emerging as key mediators of pathogenesis in
Parkinson's disease. Our understanding of the exact contribution of alpha-synuclein …