The transcription factor RUNX1 plays a crucial role in hematopoiesis. RUNX1 regulates both
differentiation and proliferation of hematopoietic cells. Several reports have shown that …

RUNX1 is crucial for the regulation of megakaryocyte specification, maturation, and
thrombopoiesis. Runx1 possesses 2 promoters: the distal P1 and proximal P2 promoters …

OBJECTIVE: Runx1 is essential for both the establishment of hematopoiesis during
development and maintenance of adult hematopoiesis. To reveal the roles of Runx1, we …

RUNX proteins belong to a family of transcription factors essential for cellular proliferation,
differentiation, and apoptosis with emerging data implicating RUNX3 in haematopoiesis and …

The Runx1/core binding factor-β (CBFβ) transcriptional complex is required for the
establishment of hematopoiesis during development. Despite its critical role during …

As a transcription factor in the RUNT domain core-binding factor family, RUNX1 is crucial in
multiple stages of hematopoiesis, and its mutation can cause familial platelet disorder with a …

RUNX1 transcription factor (TF) is a key regulator of megakaryocytic development and when
mutated is associated with familial platelet disorder and predisposition to acute myeloid …

RUNX1 is absolutely required for definitive hematopoiesis, but the function of RUNX1b/c,
two isoforms of human RUNX1, is unclear. We established inducible RUNX1b/c …

RUNX3 is a transcription factor dysregulated in acute myeloid leukemia (AML). However, its
role in normal myeloid development and leukemia is poorly understood. Here we investigate …

The transcription factor Runx1 is an essential regulator of definitive hematopoiesis,
megakaryocyte (MK) maturation, and lymphocyte differentiation. Runx1 mutations that …