Objective—α7 nicotinic acetylcholine receptor (α7nAChR) is a subtype of nAChR and has
been reported to be involved in hypertension end-organ damage. In this study, we tested the …

Adventitia-induced vascular remodeling plays an important role in vascular aging. However,
the mechanism remains unclear. In this study, we found that sirtuin 6 (SIRT6) expression …

Rationale: Uncontrolled growth of abdominal aortic aneurysms (AAAs) is a life-threatening
vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically …

Vascular smooth muscle cell senescence plays a pivotal role in the pathogenesis of
atherosclerosis. Anagliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor for the …

Cellular senescence has been implicated in endothelial dysfunctions affecting vascular tone
and regeneration. The molecular mechanisms of vascular senescence are poorly …

Reductions in arterial SIRT1 expression and activity with aging are linked to vascular
endothelial dysfunction. We tested the hypothesis that the specific SIRT1 activator SRT1720 …

Aims Aged arteries are characterized by attenuated vasodilator and enhanced
vasoconstrictor responses, which contribute to the development of diseases such as arterial …

Rationale: Endothelial senescence causes endothelial dysfunction, promotes atherogenesis
and contributes to age-related vascular disorders. SIRT1 is a conserved NAD+-dependent …

Cardiovascular diseases (CVDs) are a major cause of death worldwide. Due to the
prevalence of many side effects and incomplete recovery from pharmacotherapies, stem cell …

We tested the hypothesis that supplementation of nicotinamide mononucleotide (NMN), a
key NAD+ intermediate, increases arterial SIRT 1 activity and reverses age‐associated …