Objective To determine the best method to measure intrathecal immunoglobulin (Ig) M
synthesis (ITMS), a biomarker of worse prognosis in multiple sclerosis (MS). We compared …

Objective We aimed to determine in relapsing multiple sclerosis (MS) whether intrathecal
synthesis of immunoglobulin (Ig) M and IgG is associated with outcomes reflecting …

Markers predicting the course of patients with clinically isolated syndrome (CIS) toward
multiple sclerosis (MS) are urgently needed. We evaluated the predictive values of …

Objectives To evaluate intrathecal immunoglobulin M (IgM) production, as compared to
previously established risk factors, as risk factor for conversion from clinically isolated …

Background: There is emerging evidence that intrathecal IgM synthesis (ITMS) is a risk factor
for conversion to clinically defined multiple sclerosis (CDMS) in clinically isolated syndrome …

Importance Reliable biomarkers associated with disability worsening in multiple sclerosis
(MS) are still needed. Objective To determine a possible association of intrathecal IgG …

The presence of intrathecal IgM synthesis (ITMS) has been associated with an aggressive
multiple sclerosis (MS) clinical course. In the present systematic review, we aimed at …

One of the great challenges related to multiple sclerosis (MS) research is the identification of
markers of prognosis and treatment response. In the last couple of decades, an association …

Background Intrathecal immunoglobulin M (IgM) synthesis has been demonstrated in the
early disease stages of multiple sclerosis (MS) as a predictor factor of a worsening disease …

Abstract Objectives Intrathecally synthesized IgM can be seen not only in the cerebrospinal
fluid (CSF) in infectious and inflammatory diseases of the central nervous system, but also in …