Approximately 10% of breast cancers are associated with the inheritance of a pathogenic
variant (PV) in one of the breast cancer susceptibility genes. Multiple breast cancer …

Simple Summary TP53 variants detected in blood represent a main genetic cause of breast
cancers occurring before 31 years of age. TP53 being included in most of the cancer gene …

Pathogenic germline variants in TP53 predispose carriers to the multi‐cancer Li‐Fraumeni
syndrome (LFS). Widespread multigene panel testing is identifying TP53 pathogenic …

Germline TP53 pathogenic variants are rare but associated with a high risk of cancer; they
are often identified in the context of clinically diagnosed Li–Fraumeni syndrome …

Purpose This review describes the prevalence of germline TP53 mutations, the risk of breast
cancer and other cancers in mutation carriers and management implications for women with …

Breast cancer is the most common tumor in women with Li-Fraumeni Syndrome (LFS), an
inherited cancer syndrome associated with germline mutations in the TP53 tumor …

Background Germline TP53 mutations are associated with Li-Fraumeni syndrome, a severe
and rare hereditary cancer syndrome. Despite the rarity of germline TP53 mutations, the …

The prevalence and clinical relevance of TP53 germline mutations in a large unselected
breast cancer series are largely unknown. Here, we determined TP53 germline mutations in …

BACKGROUND: Germline TP53 mutations predispose to early onset breast cancer in
women and are associated with Li‐Fraumeni syndrome. Published data on the pathological …

Germline TP53 mutations may be responsible for a large fraction (15–20%) of all inherited
cancers. Although mutations are detectable by sequencing, counseling and follow-up …