The Multifunctional Family of Mammalian Fatty Acid–Binding Proteins

J Storch, B Corsico - Annual review of nutrition, 2023 - annualreviews.org
Fatty acid–binding proteins (FABPs) are small lipid-binding proteins abundantly expressed
in tissues that are highly active in fatty acid (FA) metabolism. Ten mammalian FABPs have …

Tissue-specific functions in the fatty acid-binding protein family

J Storch, AE Thumser - Journal of Biological Chemistry, 2010 - ASBMB
The intracellular fatty acid-binding proteins (FABPs) are abundantly expressed in almost all
tissues. They exhibit high affinity binding of a single long-chain fatty acid, with the exception …

New insights into the structure and function of fatty acid-binding proteins

AW Zimmerman, JH Veerkamp - Cellular and Molecular Life Sciences …, 2002 - Springer
Fatty acid-binding proteins (FABPs) are members of a superfamily of lipid-binding proteins,
and occur intracellularly in vertebrates and invertebrates. This review presents recent …

Fatty acid binding proteins: tissue-specific functions in health and disease

AE Thumser, JB Moore, NJ Plant - Current Opinion in Clinical …, 2014 - journals.lww.com
Fatty acid binding proteins: tissue-specific functions in he... : Current Opinion in Clinical
Nutrition & Metabolic Care Fatty acid binding proteins: tissue-specific functions in health and …

Fatty acid-binding proteins: functional understanding and diagnostic implications

H Xu, A Diolintzi, J Storch - Current Opinion in Clinical Nutrition & …, 2019 - journals.lww.com
The nine fatty acid-binding members of the FABP family have unique tissue-specific
functions and important secondary effects on tissues in which they are not expressed. For …

Role of fatty acid binding proteins (FABPs) in cancer development and progression

IH McKillop, CA Girardi, KJ Thompson - Cellular signalling, 2019 - Elsevier
Fatty acid binding proteins (FABPs) are small, water soluble proteins that bind long chain
fatty acids and other biologically active ligands to facilitate intracellular localization. Twelve …

Structural and functional analysis of fatty acid-binding proteins

J Storch, L McDermott - Journal of lipid research, 2009 - ASBMB
The mammalian FA-binding proteins (FABPs) bind long-chain FA with high affinity. The large
number of FABP types is suggestive of distinct functions in specific tissues. Multiple …

Cytoplasmic fatty acid-binding proteins: emerging roles in metabolism and atherosclerosis

JB Boord, S Fazio, MRF Linton - Current opinion in lipidology, 2002 - journals.lww.com
Cytoplasmic fatty acid-binding proteins (FABPs) are a family of proteins, expressed in a
tissue-specific manner, that bind fatty acid ligands and are involved in shuttling fatty acids to …

Liver fatty acid-binding protein and obesity

BP Atshaves, GG Martin, HA Hostetler… - The Journal of nutritional …, 2010 - Elsevier
While low levels of unesterified long chain fatty acids (LCFAs) are normal metabolic
intermediates of dietary and endogenous fat, LCFAs are also potent regulators of key …

Historic overview of studies on fatty acid-binding proteins

RK Ockner - Molecular and cellular biochemistry, 1990 - Springer
Fatty acid-binding proteins (FABPs) were first identified in the cytosol of rat intestinal mucosa
during studies on the regulation of intestinal fatty acid uptake. The subsequent finding of …