Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
The mechanism of mitochondrial damage, a key contributor to renal tubular cell death during
acute kidney injury, remains largely unknown. Here, we have demonstrated a striking …
acute kidney injury, remains largely unknown. Here, we have demonstrated a striking …
Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis
SG Cho, Q Du, S Huang… - American Journal of …, 2010 - journals.physiology.org
Recent studies revealed a striking morphological change of mitochondria during apoptosis.
Mitochondria become fragmented and notably, the fragmentation contributes to …
Mitochondria become fragmented and notably, the fragmentation contributes to …
[HTML][HTML] Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology
Mitochondria are a class of dynamic organelles that constantly undergo fission and fusion.
Mitochondrial dynamics is governed by a complex molecular machinery and finely tuned by …
Mitochondrial dynamics is governed by a complex molecular machinery and finely tuned by …
Mitochondrial energetics in the kidney
P Bhargava, RG Schnellmann - Nature Reviews Nephrology, 2017 - nature.com
The kidney requires a large number of mitochondria to remove waste from the blood and
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …
[HTML][HTML] Mitochondrial dysfunction in kidney injury, inflammation, and disease: Potential therapeutic approaches
D Bhatia, A Capili, ME Choi - Kidney research and clinical practice, 2020 - ncbi.nlm.nih.gov
Mitochondria are energy-producing organelles that not only satisfy the high metabolic
demands of the kidney but sense and respond to kidney injury-induced oxidative stress and …
demands of the kidney but sense and respond to kidney injury-induced oxidative stress and …
Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis
C Brooks, SG Cho, CY Wang… - American Journal of …, 2011 - journals.physiology.org
Recent studies have shown mitochondrial fragmentation during cell stress and have
suggested a role for the morphological change in mitochondrial injury and ensuing …
suggested a role for the morphological change in mitochondrial injury and ensuing …
Dynamin-related protein 1 deficiency promotes recovery from AKI
The proximal tubule epithelium relies on mitochondrial function for energy, rendering the
kidney highly susceptible to ischemic AKI. Dynamin-related protein 1 (DRP1), a mediator of …
kidney highly susceptible to ischemic AKI. Dynamin-related protein 1 (DRP1), a mediator of …
Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis
Y Wang, M Lu, L Xiong, J Fan, Y Zhou, H Li… - Cell death & …, 2020 - nature.com
Excessive mitochondrial fission acts as a pro-proliferative marker in some cancers and
organ fibrosis; its potential role in renal fibroblast activation and fibrogenesis has never been …
organ fibrosis; its potential role in renal fibroblast activation and fibrogenesis has never been …
Numb depletion promotes Drp1-mediated mitochondrial fission and exacerbates mitochondrial fragmentation and dysfunction in acute kidney injury
Z Liu, H Li, J Su, S Xu, F Zhu, J Ai, Z Hu… - Antioxidants & redox …, 2019 - liebertpub.com
Aims: Mitochondrial fragmentation is a crucial mechanism contributing to tubular cell
apoptosis during acute kidney injury (AKI). However, the mechanism of modulating …
apoptosis during acute kidney injury (AKI). However, the mechanism of modulating …
Mitochondria-targeted therapies for acute kidney injury
Acute kidney injury (AKI) is a serious clinical condition with no effective treatment. Tubular
cells are key targets in AKI. Tubular cells and, specifically, proximal tubular cells are …
cells are key targets in AKI. Tubular cells and, specifically, proximal tubular cells are …
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