The mechanism of mitochondrial damage, a key contributor to renal tubular cell death during
acute kidney injury, remains largely unknown. Here, we have demonstrated a striking …

Recent studies revealed a striking morphological change of mitochondria during apoptosis.
Mitochondria become fragmented and notably, the fragmentation contributes to …

Mitochondria are a class of dynamic organelles that constantly undergo fission and fusion.
Mitochondrial dynamics is governed by a complex molecular machinery and finely tuned by …

The kidney requires a large number of mitochondria to remove waste from the blood and
regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these …

Mitochondria are energy-producing organelles that not only satisfy the high metabolic
demands of the kidney but sense and respond to kidney injury-induced oxidative stress and …

Recent studies have shown mitochondrial fragmentation during cell stress and have
suggested a role for the morphological change in mitochondrial injury and ensuing …

The proximal tubule epithelium relies on mitochondrial function for energy, rendering the
kidney highly susceptible to ischemic AKI. Dynamin-related protein 1 (DRP1), a mediator of …

Excessive mitochondrial fission acts as a pro-proliferative marker in some cancers and
organ fibrosis; its potential role in renal fibroblast activation and fibrogenesis has never been …

Aims: Mitochondrial fragmentation is a crucial mechanism contributing to tubular cell
apoptosis during acute kidney injury (AKI). However, the mechanism of modulating …

Acute kidney injury (AKI) is a serious clinical condition with no effective treatment. Tubular
cells are key targets in AKI. Tubular cells and, specifically, proximal tubular cells are …