Today, it is well-known that the interactions and secretion within the tumour are crucial to
consider for cancer therapy. Some novel cancer therapy modalities such as immunotherapy …

Chemotherapy remains the mainstay of treatment for both early stage as well as metastatic
tumors. Paclitaxel (PTX), a novel anticancer drug, is a prominent taxane which is active …

Paclitaxel is a widely used anti-tumor chemotherapeutic drug. Solvent-based paclitaxel
causes bone marrow suppression, allergic reactions, neurotoxicity and systemic toxicity …

There are several interactions within the tumor microenvironment (TME) that affect the
response of cancer cells to therapy. There are also a large number of cells and secretions in …

Paclitaxel is a chemotherapeutic drug which has clinical activity against several solid
tumours including ovarian and metastatic breast cancers. Despite extensive preclinical …

This report addresses the determinants ofthe rate and extent of paclitaxelaccumulation in
tumors. In a 2-dimensionalsystem such as monolayers where the drug isdirectly in contact …

The limited penetration of paclitaxel into solid tumors may limit its therapeutic efficacy. We
recently showed a correlation between an increase in interstitial space and an enhancement …

Paclitaxel, an effective antitumor agent, is formulated in various vehicles serving as carriers
to deliver the hydrophobic paclitaxel to tissue. The approved formulations in the US are …

Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is
considered to be one of the most successful natural anticancer drugs available. This study …

Nonlinear disposition of paclitaxel (Taxol) in cancer patients has been described in several
studies, but the underlying mechanism is still a matter of speculation. Previously, we have …