The Strategy of Targeting Peroxisome Proliferator-Activated Receptor (PPAR) in the Treatment of Neuropsychiatric Disorders

F Matrisciano, G Pinna - Neuroinflammation, Gut-Brain Axis and Immunity …, 2023 - Springer
Peroxisome proliferator-activated receptors (PPARs) are nonsteroid nuclear receptors and
transcription factors that regulate several neuroinflammatory and metabolic processes …

Unlocking new avenues for neuropsychiatric disease therapy: the emerging potential of Peroxisome proliferator-activated receptors as promising therapeutic targets

AD Dey, A Mannan, S Dhiman, TG Singh - Psychopharmacology, 2024 - Springer
Rationale Peroxisome proliferator-activated receptors (PPARs) are transcription factors that
regulate various physiological processes such as inflammation, lipid metabolism, and …

[HTML][HTML] Is there a future for PPARs in the treatment of neuropsychiatric disorders?

M Tufano, G Pinna - Molecules, 2020 - mdpi.com
Recently, peroxisome proliferator-activated receptor (PPAR)-α and γ isoforms have been
gaining consistent interest in neuropathology and treatment of neuropsychiatric disorders …

Therapeutic prospects of PPARs in psychiatric disorders: a comprehensive review

B Rolland, J Deguil, R Jardri, O Cottencin… - Current drug …, 2013 - ingentaconnect.com
Peroxisome Proliferator-Activated Receptors (PPARs) are a family of nuclear receptors
whose activation modulates the gene expression that underlies both the glucid-lipid and the …

[HTML][HTML] Emerging therapeutic role of PPAR–α in cognition and emotions

KE Nisbett, G Pinna - Frontiers in Pharmacology, 2018 - frontiersin.org
Neurosteroids and the endocannabinoid system are increasing in relevance as themes in
the studies of many disorders and diseases (Berardi et al., 2016; Basavarajappa et al., 2017; …

[HTML][HTML] PPARα signaling: A candidate target in psychiatric disorder management

S Scheggi, G Pinna, G Braccagni, MG De Montis… - Biomolecules, 2022 - mdpi.com
Peroxisome proliferator-activator receptors (PPARs) regulate lipid and glucose metabolism,
control inflammatory processes, and modulate several brain functions. Three PPAR isoforms …

[HTML][HTML] Repurposing peroxisome proliferator-activated receptor agonists in neurological and psychiatric disorders

C Sagheddu, M Melis, AL Muntoni, M Pistis - Pharmaceuticals, 2021 - mdpi.com
Common pathophysiological mechanisms have emerged for different neurological and
neuropsychiatric conditions. In particular, mechanisms of oxidative stress, immuno …

[HTML][HTML] Nuclear peroxisome proliferator activated receptor-gamma (PPARγ) as a therapeutic target to treat neurodegeneration and dependence elicited by drugs of …

R Ciccocioppo, M Ubaldi - Neural Regeneration Research, 2021 - journals.lww.com
Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription
factors that are located in the cytoplasm. After activation by specific ligands, PPARs enter the …

PPAR agonists for the treatment of neuroinflammatory diseases

C Titus, MT Hoque, R Bendayan - Trends in Pharmacological Sciences, 2024 - cell.com
Peroxisome proliferator-activated receptors [PPARs; PPARα, PPARβ/δ (also known as
PPARδ), and PPARγ] widely recognized for their important role in glucose/lipid homeostasis …

PPARγ as a therapeutic target in central nervous system diseases

S Sundararajan, Q Jiang, M Heneka… - Neurochemistry …, 2006 - Elsevier
Diseases of the central nervous system present a challenge for the development of new
therapeutic agents. Nuclear receptors are ligand-activated transcription factors that have …