The Strategy of Targeting Peroxisome Proliferator-Activated Receptor (PPAR) in the Treatment of Neuropsychiatric Disorders
F Matrisciano, G Pinna - Neuroinflammation, Gut-Brain Axis and Immunity …, 2023 - Springer
Peroxisome proliferator-activated receptors (PPARs) are nonsteroid nuclear receptors and
transcription factors that regulate several neuroinflammatory and metabolic processes …
transcription factors that regulate several neuroinflammatory and metabolic processes …
Unlocking new avenues for neuropsychiatric disease therapy: the emerging potential of Peroxisome proliferator-activated receptors as promising therapeutic targets
Rationale Peroxisome proliferator-activated receptors (PPARs) are transcription factors that
regulate various physiological processes such as inflammation, lipid metabolism, and …
regulate various physiological processes such as inflammation, lipid metabolism, and …
[HTML][HTML] Is there a future for PPARs in the treatment of neuropsychiatric disorders?
Recently, peroxisome proliferator-activated receptor (PPAR)-α and γ isoforms have been
gaining consistent interest in neuropathology and treatment of neuropsychiatric disorders …
gaining consistent interest in neuropathology and treatment of neuropsychiatric disorders …
Therapeutic prospects of PPARs in psychiatric disorders: a comprehensive review
Peroxisome Proliferator-Activated Receptors (PPARs) are a family of nuclear receptors
whose activation modulates the gene expression that underlies both the glucid-lipid and the …
whose activation modulates the gene expression that underlies both the glucid-lipid and the …
[HTML][HTML] Emerging therapeutic role of PPAR–α in cognition and emotions
KE Nisbett, G Pinna - Frontiers in Pharmacology, 2018 - frontiersin.org
Neurosteroids and the endocannabinoid system are increasing in relevance as themes in
the studies of many disorders and diseases (Berardi et al., 2016; Basavarajappa et al., 2017; …
the studies of many disorders and diseases (Berardi et al., 2016; Basavarajappa et al., 2017; …
[HTML][HTML] PPARα signaling: A candidate target in psychiatric disorder management
Peroxisome proliferator-activator receptors (PPARs) regulate lipid and glucose metabolism,
control inflammatory processes, and modulate several brain functions. Three PPAR isoforms …
control inflammatory processes, and modulate several brain functions. Three PPAR isoforms …
[HTML][HTML] Repurposing peroxisome proliferator-activated receptor agonists in neurological and psychiatric disorders
C Sagheddu, M Melis, AL Muntoni, M Pistis - Pharmaceuticals, 2021 - mdpi.com
Common pathophysiological mechanisms have emerged for different neurological and
neuropsychiatric conditions. In particular, mechanisms of oxidative stress, immuno …
neuropsychiatric conditions. In particular, mechanisms of oxidative stress, immuno …
[HTML][HTML] Nuclear peroxisome proliferator activated receptor-gamma (PPARγ) as a therapeutic target to treat neurodegeneration and dependence elicited by drugs of …
R Ciccocioppo, M Ubaldi - Neural Regeneration Research, 2021 - journals.lww.com
Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription
factors that are located in the cytoplasm. After activation by specific ligands, PPARs enter the …
factors that are located in the cytoplasm. After activation by specific ligands, PPARs enter the …
PPAR agonists for the treatment of neuroinflammatory diseases
C Titus, MT Hoque, R Bendayan - Trends in Pharmacological Sciences, 2024 - cell.com
Peroxisome proliferator-activated receptors [PPARs; PPARα, PPARβ/δ (also known as
PPARδ), and PPARγ] widely recognized for their important role in glucose/lipid homeostasis …
PPARδ), and PPARγ] widely recognized for their important role in glucose/lipid homeostasis …
PPARγ as a therapeutic target in central nervous system diseases
S Sundararajan, Q Jiang, M Heneka… - Neurochemistry …, 2006 - Elsevier
Diseases of the central nervous system present a challenge for the development of new
therapeutic agents. Nuclear receptors are ligand-activated transcription factors that have …
therapeutic agents. Nuclear receptors are ligand-activated transcription factors that have …