Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …

Major advances have occurred in recent years in our understanding of HIV-1 assembly,
release and maturation, as work in this field has been propelled forwards by developments …

Retroviral assembly proceeds through a series of concerted events that lead to the formation
and release of infectious virion particles from the infected cell. Upon translation, structural …

Etiology, transmission and protection: Transmission of HIV, the causative agent of AIDS,
occurs predominantly through bodily fluids. Factors that significantly alter the risk of HIV …

The life cycle of HIV‐1 involves a series of steps necessary for the successful infection of
human target cells. First the RNA genome enters the cytoplasm after the fusion of the viral …

Studies on HIV virology and pathogenesis address the complex mechanisms that result in
the HIV infection of the cell and destruction of the immune system. These studies are …

Since the discovery of human immunodeficiency virus (HIV) as the etiologic agent of
acquired immune deficiency syndrome (AIDS) more than a decade ago, tremendous …

Assembly of human immunodeficiency virus type 1 is driven by oligomerization of the Gag
polyprotein at the plasma membrane of an infected cell, leading to membrane envelopment …

A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …

HIV-1 has been the target of intensive research at the molecular and biochemical levels for>
25 years. Collectively, this work has led to a detailed understanding of viral replication and …