Short-chain fatty acids as a potential treatment for infections: a closer look at the lungs

MG Machado, V Sencio, F Trottein - Infection and immunity, 2021 - Am Soc Microbiol
Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via
the fermentation of complex carbohydrates and fibers. Evidence suggests that SCFAs play a …

Short Chain Fatty Acids: Fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases

S Ashique, G De Rubis, E Sirohi, N Mishra… - Chemico-biological …, 2022 - Elsevier
The human microbiota is fundamental to correct immune system development and balance.
Dysbiosis, or microbial content alteration in the gut and respiratory tract, is associated with …

Microbial regulation of host physiology by short-chain fatty acids

B van der Hee, JM Wells - Trends in Microbiology, 2021 - cell.com
Our ancestral diet consisted of much more nondigestible fiber than that of many societies
today. Thus, from an evolutionary perspective the human genome and its physiological and …

[HTML][HTML] Dual role of microbiota-derived short-chain fatty acids on host and pathogen

R Mirzaei, E Dehkhodaie, B Bouzari, M Rahimi… - Biomedicine & …, 2022 - Elsevier
A growing body of documents shows microbiota produce metabolites such as short-chain
fatty acids (SCFAs) as crucial executors of diet-based microbial influence the host and …

Impact of the microbial derived short chain fatty acid propionate on host susceptibility to bacterial and fungal infections in vivo

E Ciarlo, T Heinonen, J Herderschee, C Fenwick… - Scientific reports, 2016 - nature.com
Short chain fatty acids (SCFAs) produced by intestinal microbes mediate anti-inflammatory
effects, but whether they impact on antimicrobial host defenses remains largely unknown …

Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections

LM Ney, M Wipplinger, M Grossmann… - Open …, 2023 - royalsocietypublishing.org
The human intestinal microbiome substantially affects human health and resistance to
infections in its dynamic composition and varying release of microbial-derived metabolites …

[HTML][HTML] Microbiota-derived short chain fatty acids: Their role and mechanisms in viral infections

C Feng, C Jin, K Liu, Z Yang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Microbiota-derived short-chain fatty acids (SCFAs) are crucial for protecting the intestinal
barrier and regulating the immune response during infections. Recent studies show that viral …

Short-chain fatty acids in diseases

D Zhang, YP Jian, YN Zhang, Y Li, LT Gu… - Cell Communication and …, 2023 - Springer
Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation
of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate …

[PDF][PDF] Anti-infective activities of long-chain fatty acids against foodborne pathogens

C Borreby, EMS Lillebæk… - FEMS microbiology …, 2023 - academic.oup.com
Free fatty acids (FFAs) have long been acknowledged for their antimicrobial activity. More
recently, long-chain FFAs (> 12 carbon atoms) are receiving increased attention for their …

Regulation of bacterial pathogenesis by intestinal short-chain fatty acids

Y Sun, MXD O'Riordan - Advances in applied microbiology, 2013 - Elsevier
The human gut microbiota is inextricably linked to health and disease. One important
function of the commensal organisms living in the intestine is to provide colonization …