Certain guanine-rich (G-rich) DNA and RNA molecules can associate intermolecularly or
intramolecularly to form four stranded or “quadruplex” structures, which have unusual …

G-quadruplexes constitute a unique class of nucleic acid structures formed by G-rich
oligonucleotides of DNA-or RNA-type. Depending on their chemical nature, loops length …

Nucleic acid aptamers are single-stranded DNA or RNA molecules identified to recognize
with high affinity specific targets including proteins, small molecules, ions, whole cells and …

AGRO100 (also known as AS1411) is a G-rich oligonucleotide that has long been
established as a potent anti-cancer aptamer. However, the structure of AGRO100 remained …

Background AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-
quadruplex structures. It was identified based on its cancer-selective antiproliferative activity …

Though a variety of different non-canonical nucleic acids conformations have been
recognized, G-quadruplex structures are probably the structural motifs most commonly found …

Single‐stranded guanosine‐rich oligodeoxyribonucleotides (GROs) have a propensity to
form quadruplex structures that are stabilized by G‐quartets. In addition to intense …

In development by Antisoma plc, AS-1411 is the first oligodeoxynucleotide aptamer to reach
phase I and II clinical trials for the potential treatment of cancers, including acute …

Aptamers are short DNA-or RNA-based oligonucleotides selected from large combinatorial
pools of sequences for their capacity to efficiently recognize targets ranging from small …

Highly specific and tight-binding nucleic acid aptamers have been selected against a variety
of molecular targets for over 20 years. A significant proportion of these oligonucleotides …