The pre-ovulatory surge of gonadotrophins triggers a marked and obligatory increase in
follicular prostaglandin synthesis prior to ovulation, and the cyclooxygenase (COX) enzyme …

Normal ovulation in mice requires PG-endoperoxide synthase 2 (cyclooxygenase-2; COX-2)
expression. This study examined the role of the oocyte and other factors in regulating steady …

Cyclooxygenase (COX) is the rate-limiting enzyme in the biosynthesis of PGs. PGs together
with ovarian steroids play important regulatory roles in the establishment and maintenance …

Prostaglandins could be involved in various aspects of final differentiation of ovarian
follicles. Prostaglandins are generated by the cyclooxygenase (cox) pathway. Until now, the …

Follicular prostaglandin concentrations increase following the gonadotrophin surge in
domestic animals and rodents~ 10 h before follicle rupture, suggesting a unifying role for …

The precise genetic and molecular defects underlying epithelial ovarian cancer (EOC)
remain largely unknown, and treatment options for patients with advanced disease are …

Abstract Inhibition of cyclooygenase-2 (COX-2) catalytic activity has proven successful in
restricting the growth of epithelial-derived cancers in vivo. Whether COX-2 inhibitor therapy …

Timing is of the essence—especially in the unique biological process of ovulation. The LH
surge is released in response to a critical threshold of estradiol coming from the preovulatory …

Objectives. Cyclooxygenase-1 and 2 (COX-1 and COX-2) play important roles in normal
physiology and are often dysregulated in neoplastic tissues. The present study determines …

Mice carrying a null mutation for either of the two cyclooxygenase (COX) isoenzymes,
necessary for prostanoid production, exhibit several isotype-specific reproductive …