The clinical and genetic features in Chinese children with steroid-resistant or early-onset nephrotic syndrome: a multicenter cohort study

X Zhu, Y Zhang, Z Yu, L Yu, W Huang, S Sun… - Frontiers in …, 2022 - frontiersin.org
Steroid-resistant nephrotic syndrome (SRNS) is one of the major causes of end-stage kidney
disease (ESKD) in children and young adults. For approximately 30% of children with SRNS …

Spectrum of mutations in Chinese children with steroid-resistant nephrotic syndrome

F Wang, Y Zhang, J Mao, Z Yu, Z Yi, LI Yu, J Sun… - Pediatric …, 2017 - Springer
Background The aim of this study was to elucidate whether genetic screening test results of
pediatric patients with steroid-resistant nephrotic syndrome (SRNS) vary with ethnicity …

[HTML][HTML] Monogenic Causes Identified in 23.68% of Children with Steroid-Resistant Nephrotic Syndrome: A Single-Centre Study

L Zhang, F Zhao, G Ding, Y Chen, S Zhao, Q Chen… - Kidney …, 2024 - karger.com
Introduction: Steroid-resistant nephrotic syndrome (SRNS) is the second most common
cause of end-stage kidney disease in children, mostly associated with focal segmental …

A systematic analysis of major susceptible genes in childhood-onset steroid-resistant nephrotic syndrome

Y Li, Q He, Y Wang, X Dang, X Wu, X Li… - Annals of Clinical & …, 2019 - Assoc Clin Scientists
Aim Nephrotic syndrome is a urinary disease, causing high morbidity and mortality.
However, the mutation prevalence of major susceptible genes in childhood-onset steroid …

[HTML][HTML] Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management

A Bierzynska, HJ McCarthy, K Soderquest, ES Sen… - Kidney international, 2017 - Elsevier
Steroid Resistant Nephrotic Syndrome (SRNS) in children and young adults has differing
etiologies with monogenic disease accounting for 2.9–30% in selected series. Using whole …

Mutational spectrum and novel candidate genes in Chinese children with sporadic steroid-resistant nephrotic syndrome

J Li, L Wang, L Wan, T Lin, W Zhao, H Cui, H Li… - Pediatric …, 2019 - nature.com
Abstract Background Approximately 10–20% of children with idiopathic nephrotic syndrome
(NS) fail to respond to steroid therapy. NS is divided into steroid-sensitive NS (SSNS) and …

High detection rate for disease-causing variants in a cohort of 30 Iranian pediatric steroid resistant nephrotic syndrome cases

M Najafi, KM Riedhammer, A Rad, PN Torbati… - Frontiers in …, 2022 - frontiersin.org
Background Steroid resistant nephrotic syndrome (SRNS) represents a significant renal
disease burden in childhood and adolescence. In contrast to steroid sensitive nephrotic …

Follow-up results of patients with ADCK4 mutations and the efficacy of CoQ10 treatment

M Atmaca, B Gulhan, E Korkmaz, M Inozu… - Pediatric …, 2017 - Springer
Background ADCK4-related glomerulopathy is an important differential diagnosis in
adolescents with steroid-resistant nephrotic syndrome (SRNS) and/or chronic kidney …

Genetic study in Korean pediatric patients with steroid-resistant nephrotic syndrome or focal segmental glomerulosclerosis

E Park, C Lee, NKD Kim, YH Ahn, YS Park… - Journal of clinical …, 2020 - mdpi.com
Steroid-resistant nephrotic syndrome (SRNS) is one of the major causes of end-stage renal
disease (ESRD) in childhood and is mostly associated with focal segmental …

Novel mutation patterns in children with steroid-resistant nephrotic syndrome

N Prasad, J Meyyappan, M Dhanorkar… - Clinical Kidney …, 2024 - academic.oup.com
Background Idiopathic nephrotic syndrome (NS) in children poses treatment challenges,
with a subset developing steroid-resistant nephrotic syndrome (SRNS). Genetic factors play …