Background DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-
phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) …

Epigenome-wide association studies, which searches for blood-based DNA methylation
signatures associated with environmental exposures and/or disease susceptibilities, is a …

Ethnic differences in non-communicable disease risk have been described between
individuals of South Asian and European ethnicity that are only partially explained by …

Cardiovascular diseases (CVDs) are the leading causes of death worldwide and represent a
substantial economic burden on public health care systems. Epigenetic markers have …

Background DNA methylation is a key epigenetic mechanism that is suggested to be
associated with blood lipid levels. We aimed to identify CpG sites at which DNA methylation …

DNA methylation (DNAm) has been revealed to play a role in various diseases. Here we
performed epigenome-wide screening and validation to identify mortality-related DNAm …

Background Pinpointing genetic impacts on DNA methylation can improve our
understanding of pathways that underlie gene regulation and disease risk. Results We …

Background Disease risk and incidence between males and females reveal differences, and
sex is an important component of any investigation of the determinants of phenotypes or …

Assessing DNA methylation profiles in human blood has become a major focus of
epidemiologic inquiry. Understanding variability in CpG-specific DNA methylation over …

Background Modification of DNA by methylation of cytosines at CpG dinucleotides is a
widespread phenomenon that leads to changes in gene expression, thereby influencing and …