Cancer cells harbor many genetic mutations and gene expression profiles different from
normal cells. Patient-derived cancer cells (PDCC) are preferred materials in cancer study …

Lung cancer remains a major health problem despite the considerable research into
prevention and treatment methods. Through a deeper understanding of tumors, patient …

Human lung cancer is one of the leading causes of death worldwide, with nearly 2 million of
new cases diagnosed each year, often too late for a successful therapeutic intervention. In …

Simple Summary Lung cancer, responsible for nearly 20% of global cancer-related deaths
annually, is the leading cause of cancer mortality. Traditional treatments, like chemotherapy …

Lung cancer thrives in a complex multicellular tumor microenvironment (TME) that impacts
tumor growth, metastasis, response, and resistance to therapy. While orthotopic murine lung …

Mathematical models of non-small-cell lung cancer are powerful tools that use clinical and
experimental data to describe various aspects of tumorigenesis. The developed algorithms …

Lung malignancies accounted for 11% of cancers worldwide in 2020 and remained the
leading cause of cancer deaths. About 80% of lung cancers belong to non-small cell lung …

Simple Summary Presently, the investigation of the tumor is carried out using different
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …

Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …

Evolving understanding of structural and biological complexity of tumors has stimulated
development of physiologically relevant tumor models for cancer research and drug …