The effects of short-and long-term load-controlled compression on the levels of aggrecan
mRNA have been determined. Results show that a compressive stress of 0.1 MPa on bovine …

The goal of this study was to examine the simultaneous effects of mechanical compression
of chondrocytes on mRNA expression and macromolecular synthesis of aggrrecan and type …

The effect of hydrostatic pressure on proteoglycan (PG) metabolism of chondrocyte cultures
was examined using a specially designed test chamber. Primary cultures of bovine articular …

Chondrocytes are influenced by mechanical forces to remodel cartilage extracellular matrix.
Previous studies have demonstrated the effects of mechanical forces on changes in …

Although the effects of mechanical loading on chondrocyte metabolic activities have been
extensively characterized, the sequence of events through which extracellular mechanical …

This study tested the effects of hydrostatic pressure (10 MPa) on adult articular chondrocyte
mRNA and extracellular matrix synthesis in vitro. High density primary cultures of bovine …

The differential effects of static compression and recovery from compression on biosynthesis
and biosynthetic pathways of aggrecan, link protein, and hyaluronan were assessed. During …

This study addressed the hypothesis that duration and magnitude of applied intermittent
hydrostatic pressure (IHP) are critical parameters in regulation of normal human articular …

Previous studies have shown that static equilibrium compression of cartilage tissue in vivo
and in vitro decreases chondrocyte synthesis of aggrecan molecules. In order to identify …

Objective To investigate the effects of increasing extracellular osmolality on aggrecan gene
expression and cell size in cultured chondrocytes. Design Aggrecan promoter activity and …