Diabetic nephropathy (DN) is considered the main cause of kidney disease in which
myofibroblasts lead to renal fibrosis. Macrophages were recently identified as the major …

Background: Alternatively activated macrophages (M2 macrophages) are able to reduce
renal injury in murine adriamycin nephropathy. However, the effect of M2 macrophages in …

Background In clinicopathological studies of cellular remodeling in the progression of
diabetic nephropathy, it has not been well described whether tissue macrophage numbers …

Crescentic glomerulonephritis (GN) in Wistar-Kyoto rats progresses to lethal kidney failure
by macrophage (Mφ)-mediated mechanisms. Mφs in nephritic glomeruli express adenosine …

Background. Renal fibrosis is central to the progression of diabetic nephropathy; however,
the mechanisms responsible for fibroblast and matrix accumulation in this disease are only …

Background/Aims: Diabetic nephropathy is one of the main causes of end-stage renal
disease. The present study investigated the effect of mononuclear cell (MC) therapy in rats …

Macrophages in mouse type 2 diabetic nephropathy: Correlation with diabetic state and
progressive renal injury. Background Macrophage-mediated renal injury has been …

Abstract Background Endothelial-myofibroblast transition (EndMT) has been implicated in
the pathogenesis of diabetic renal fibrosis. In this study, the effect of the complement …

Alternatively activated macrophages (M2) have regenerative properties and shown promise
as cell therapy in chronic kidney disease. However, M2 plasticity is one of the major hurdles …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease globally. The
primary initiating mechanism in DN is hyperglycemia-induced vascular dysfunction, but its …