Resistance to β-lactam antibiotics in Gram-negative bacteria is commonly associated with
production of β-lactamases, including extended-spectrum β-lactamases (ESBLs) and …

As the incidence of Gram-negative bacterial infections for which few effective treatments
remain increases, so does the contribution of drug-hydrolyzing β-lactamase enzymes to this …

Avibactam, which is the first non-β-lactam β-lactamase inhibitor to be introduced for clinical
use, is a broad-spectrum serine β-lactamase inhibitor with activity against class A, class C …

Abstract β-Lactamase inhibitors (BLIs) have played an important role in combatting β-lactam
resistance in Gram-negative bacteria, but their effectiveness has diminished with the …

Carbapenem-resistant Enterobacteriaceae are amongst the most feared pathogens due to
severely limited treatment options. In response to this threat, three novel β-lactamase …

Antibiotic resistance, and the emergence of pan-resistant clinical isolates, seriously
threatens our capability to treat bacterial diseases, including potentially deadly hospital …

β-lactam antibiotics (BLAs) are crucial molecules among antibacterial drugs, but the
increasing emergence of resistance to them, developed by bacteria producing β-lactamase …

ABSTRACT Introduction: Antimicrobial resistance in Gram-negative pathogens is a
significant threat to global health. β-Lactams (BL) are one of the safest and most-prescribed …

β-Lactams are the most widely used class of antibiotics. Since the discovery of
benzylpenicillin in the 1920s, thousands of new penicillin derivatives and related β-lactam …

ABSTRACT β-Lactamase production is the major β-lactam resistance mechanism in Gram-
negative bacteria. β-Lactamase inhibitors (BLIs) efficacious against serine β-lactamase …