Spermatogenesis is completely dependent on the pituitary hormone follicle-stimulating
hormone (FSH) and androgens locally produced in response to luteinising hormone (LH) …

Introduction The adult testis has two important roles, namely the production of spermatozoa
(fertility) and the secretion of testosterone which is needed for the expression of secondary …

Over the past five decades, intense research using various animal models, innovative
technologies notably genetically modified mice and wider use of stereological methods …

It has been clear for decades that testosterone is a necessary prerequisite for the
maintenance of established spermatogenesis in the adult testes, and for the restoration of …

A better understanding of the hormonal regulation of spermatogenesis may provide new
avenues for management of human infertility, and development of safe and reversible …

FSH and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the
Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen …

Spermatogenesis is a concerted sequence of events during maturation of spermatogonia
into spermatozoa. The process involves differential gene-expression and cell-cell interplay …

ABSTRACT A detailed understanding of the hormonal regulation of spermatogenesis is
required for the informed assessment and management of male fertility and, conversely, for …

We recently created a novel transgenic (tg) model to examine the specific gonadal actions of
FSH, distinct from LH effects, by expressing tg-FSH in gonadotropin-deficient hypogonadal …

In spite of the availability of abundant data about in vitro spermatogenesis in laboratory
animals, studies on human in vitro spermatogenesis are scarce. This study employed a …