The metabolic state represents a major hurdle for an effective adoptive T cell therapy (ACT).
Indeed, specific lipids can harm CD8+ T cell (CTL) mitochondrial integrity, leading to …

Effector, memory and exhaustion are three phenotypes of CD8+ T cell. In tumor
microenvironment (TME), metabolism dysfunction of the three should take the blame for …

CD8+ T cell longevity regulated by metabolic activity plays important roles in cancer
immunotherapy. Although in vitro–polarized, transferred IL-9–secreting CD8+ Tc9 (cytotoxic …

The functional state of T cells is a key determinant for effective antitumor immunity and
immunotherapy. Cellular metabolism, including lipid metabolism, controls T cell …

The steady flow of lactic acid (LA) from tumor cells to the extracellular space via the
monocarboxylate transporter symport system suppresses antitumor T cell immunity …

CD8+ T cells are master effectors of antitumor immunity, and their presence at tumor sites
correlates with favorable outcomes. However, metabolic constraints imposed by the tumor …

Although tumor-intrinsic fatty acid β-oxidation (FAO) is implicated in multiple aspects of
tumorigenesis and progression, the impact of this metabolic pathway on cancer cell …

Hepatocellular carcinoma (HCC) is a common cause of cancer-related death worldwide. As
obesity and diabetes become more prevalent, the contribution of non-alcoholic fatty liver …

T-cell-based therapies represent a promising strategy for cancer treatment. In this context,
cytokines are discussed as a bona fide instrument for fine-tuning T-cell biology. One …

CD 8+ T cells are key members of the adaptive immune response against infections and
cancer. As we discuss in this review, these cells can present diverse metabolic …