This review is an updated and expanded version of the five prior reviews that were
published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic …

This contribution is a completely updated and expanded version of the four prior analogous
reviews that were published in this journal in 1997, 2003, 2007, and 2012. In the case of all …

This review is an updated and expanded version of the three prior reviews that were
published in this journal in 1997, 2003, and 2007. In the case of all approved therapeutic …

This review is an updated and expanded version of two prior reviews that were published in
this journal in 1997 and 2003. In the case of all approved agents the time frame has been …

Covering: 2004 to 2006 Natural products have provided considerable value to the
pharmaceutical industry over the past half century. In particular, the therapeutic areas of …

BACKGROUND: Nature has been a source of medicinal products for millennia, with many
useful drugs developed from plant sources. Following discovery of the penicillins, drug …

It seems appropriate to emphasize the topic of natural products at a time when new
compounds are desperately needed to combat the current problems of antibiotic resistance …

Natural products and their derivatives are mainstays of our antibiotic drugs, but they are
increasingly in peril. The combination of widespread multidrug resistance in once …

This review is an updated and expanded version of a paper that was published in this
journal in 1997. The time frame has been extended in both directions to include the 22 years …

The introduction of high-throughput synthesis and combinatorial chemistry has precipitated
a global decline in the screening of natural products by the pharmaceutical industry. Some …