Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations

SC Esteves, A Zini, RM Coward, DP Evenson… - Andrologia, 2021 - Wiley Online Library
We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …

[HTML][HTML] Sperm DNA damage and its relevance in fertility treatment: A review of recent literature and current practice guidelines

JA Marinaro, PN Schlegel - International Journal of Molecular Sciences, 2023 - mdpi.com
Sperm deoxyribonucleic acid (DNA) damage has recently emerged as one of the most
controversial topics in male reproductive medicine. While level I evidence indicates that …

[HTML][HTML] The Society for Translational Medicine: clinical practice guidelines for sperm DNA fragmentation testing in male infertility

A Agarwal, CL Cho, A Majzoub… - … andrology and urology, 2017 - ncbi.nlm.nih.gov
Sperm DNA fragmentation (SDF) testing has been emerging as a valuable tool for male
fertility evaluation. While the essential role of sperm DNA integrity in human reproduction …

[HTML][HTML] Sperm DNA fragmentation: a new guideline for clinicians

A Agarwal, A Majzoub, S Baskaran… - The world journal of …, 2020 - ncbi.nlm.nih.gov
Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

Should we evaluate and treat sperm DNA fragmentation?

A Agarwal, CL Cho, SC Esteves - Current Opinion in Obstetrics …, 2016 - journals.lww.com
Sperm DNA fragmentation tests provide clinically relevant information for natural conception
and artificial reproduction independent of those derived from conventional semen …

Sperm DNA fragmentation: consequences for reproduction

L Simon, B Emery, DT Carrell - Genetic Damage in Human Spermatozoa, 2019 - Springer
DNA fragmentation, or the accumulation of single-and double-strand DNA breaks, is a
common property of sperm, and an increase in the level of sperm DNA fragmentation is …

[HTML][HTML] Controversy and consensus on indications for sperm DNA fragmentation testing in male infertility: A global survey, current guidelines, and expert …

A Agarwal, A Farkouh, R Saleh… - The world journal of …, 2023 - ncbi.nlm.nih.gov
Purpose Sperm DNA fragmentation (SDF) testing was recently added to the sixth edition of
the World Health Organization laboratory manual for the examination and processing of …

[HTML][HTML] Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

A Agarwal, A Majzoub, SC Esteves, E Ko… - Translational …, 2016 - ncbi.nlm.nih.gov
Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for
male fertility evaluation. While its detrimental implications on sperm function were …

[HTML][HTML] Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: a systematic review and meta-analysis

M Cissen, M Wely, I Scholten, S Mansell, JP Bruin… - PloS one, 2016 - journals.plos.org
Sperm DNA fragmentation has been associated with reduced fertilization rates, embryo
quality, pregnancy rates and increased miscarriage rates. Various methods exist to test …

DNA fragmentation in spermatozoa: a historical review

AS Rex, J Aagaard, J Fedder - Andrology, 2017 - Wiley Online Library
Sperm DNA Fragmentation has been extensively studied for more than a decade. In the
1940s the uniqueness of the spermatozoa protein complex which stabilizes the DNA was …