Predictive metabolomic signatures for safety assessment of metal oxide nanoparticles
The widespread use of metal oxide nanoparticles (MOx NPs) poses a risk of exposure that
may lead to adverse health effects on humans. Even though a number of toxicological …
may lead to adverse health effects on humans. Even though a number of toxicological …
Metabolomics profiling to investigate nanomaterial toxicity in vitro and in vivo
A Bannuscher, B Hellack, A Bahl, J Laloy… - …, 2020 - Taylor & Francis
Nanomaterials (NMs) can be produced in plenty of variants posing several challenges for
NM hazard and risk assessment. Metabolomic profiling of NM-treated cells and tissues …
NM hazard and risk assessment. Metabolomic profiling of NM-treated cells and tissues …
[HTML][HTML] Copper oxide nanoparticle toxicity profiling using untargeted metabolomics
MSP Boyles, C Ranninger, R Reischl, M Rurik… - Particle and fibre …, 2015 - Springer
Background The rapidly increasing number of engineered nanoparticles (NPs), and
products containing NPs, raises concerns for human exposure and safety. With this …
products containing NPs, raises concerns for human exposure and safety. With this …
[HTML][HTML] Zinc oxide nanoparticles impose metabolic toxicity by de-regulating proteome and metabolome in Saccharomyces cerevisiae
PK Babele - Toxicology Reports, 2019 - Elsevier
As zinc oxide nanoparticles are being increasingly used in various applications, it is
important to assess their potential toxic implications. Stress responses and adaptations are …
important to assess their potential toxic implications. Stress responses and adaptations are …
Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation
We demonstrate for 24 metal oxide (MOx) nanoparticles that it is possible to use conduction
band energy levels to delineate their toxicological potential at cellular and whole animal …
band energy levels to delineate their toxicological potential at cellular and whole animal …
Multi-omics approaches confirm metal ions mediate the main toxicological pathways of metal-bearing nanoparticles in lung epithelial A549 cells
The toxicity of silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs) has been associated with
their dissolution or ability to release metal ions while the toxicity of cerium dioxide (CeO2) …
their dissolution or ability to release metal ions while the toxicity of cerium dioxide (CeO2) …
Targeted metabolomics reveals differential biological effects of nanoplastics and nanoZnO in human lung cells
SL Lim, CT Ng, L Zou, Y Lu, J Chen, BH Bay… - …, 2019 - Taylor & Francis
Engineered nanomaterials are of public health concern. Recently, there has been an
increasing attention on the toxicity of nanoplastics and nanoZnO because of their increasing …
increasing attention on the toxicity of nanoplastics and nanoZnO because of their increasing …
A multi-omics approach reveals mechanisms of nanomaterial toxicity and structure–activity relationships in alveolar macrophages
A Bannuscher, I Karkossa, S Buhs, P Nollau… - …, 2020 - Taylor & Francis
In respect to the high number of released nanomaterials and their highly variable properties,
novel grouping approaches are required based on the effects of nanomaterials. Proper …
novel grouping approaches are required based on the effects of nanomaterials. Proper …
[HTML][HTML] Zinc oxide nanoparticle caused plasma metabolomic perturbations correlate with hepatic steatosis
W Zhang, Y Zhao, F Li, L Li, Y Feng, L Min… - Frontiers in …, 2018 - frontiersin.org
Zinc oxide nanoparticles (ZnO NPs), known for their chemical stability and strong adsorption,
are used in everyday items such as cosmetics, sunscreens, and prophylactic drugs …
are used in everyday items such as cosmetics, sunscreens, and prophylactic drugs …
From the cover: zinc oxide nanoparticles-induced reactive oxygen species promotes multimodal cyto-and epigenetic toxicity
In this study we evaluated and correlated the cytotoxic effects of zinc oxide nanoparticles
(ZnO-NPs) to the epigenetic modifications, using human embryonic kidney (HEK-293) cells …
(ZnO-NPs) to the epigenetic modifications, using human embryonic kidney (HEK-293) cells …