Background: Many biological, behavioral, social, and environmental factors may contribute
to the delay or prevention of cognitive decline. Purpose: To summarize evidence about …

A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

The National Institute on Aging and the Office of Medical Applications of Research of the
National Institutes of Health convened a State-of-the-Science Conference on 26–28 April …

Background: Optimal treatment to prevent or delay cognitive decline, mild cognitive
impairment (MCI), or dementia is uncertain. Purpose: To summarize current evidence on the …

Background The public health impact of cognitive decline and dementia is increasing as the
population ages. Studies exploring therapies or risk factors for cognitive impairment require …

Dementia is a rapidly growing global public health problem. Worldwide, around 50 million
people have dementia, with approximately 60% living in low-and middle-income countries …

A number of health and lifestyle factors are thought to contribute to cognitive decline
associated with age but cannot be easily modified by the individual patient. We identified 12 …

Objective: Many advances have been made in the understanding of age-related changes in
cognition. As research details the cognitive and neurobiological changes that occur in aging …

Cognition-oriented treatments–commonly categorized as cognitive training, cognitive
rehabilitation and cognitive stimulation–are promising approaches for the prevention of …

Background: Structured activities to stimulate brain function—that is, cognitive training
exercises—are promoted to slow or prevent cognitive decline, including dementia, but their …