Increasing evidence indicates that pancreatic stellate cells (PSCs) are responsible for the
stromal reaction in pancreatic ductal adenocarcinoma (PDAC). The interaction between …

Abstract Background Cyclooxygenase 2 (COX-2), the inducible form of prostaglandin G/H
synthase, is associated with several human cancers including pancreatic adenocarcinoma …

Pancreatic cancer is characterized by its late detection, aggressive growth, intense
infiltration into adjacent tissue, early metastasis, resistance to chemo-and radiotherapy and …

Pancreatic adenocarcinoma (PDAC) and chronic pancreatitis (CP) are characterized by a
desmoplastic reaction involving activated pancreatic stellate cells (PSCs). However, the …

Abstract Background Pancreatic stellate cells (PSCs) play a pivotal role in pancreatic
fibrosis, a characteristic feature of pancreatic cancer. Although it is still controversial …

Abstract Background Pancreatic stellate cells (PSCs) occupy the majority of the pancreatic
cancer microenvironment, contributing to aggressive behavior of pancreatic cancer cells …

Activated pancreatic stellate cells (PSCs) are the main effector cells in the process of
fibrosis, a major pathological feature in pancreatic diseases that including chronic …

COX-2 is upregulated in pancreatic ductal adenocarcinomas (PDAC). However, how COX-2
promotes PDAC development is unclear. While previous studies have evaluated the efficacy …

Background Several studies have described an increased cyclooxygenase-2 (COX-2)
expression in pancreatic cancer, but the role of COX-2 in tumour development and …

Pancreatic adenocarcinoma is characterized by an intense desmoplastic reaction that
surrounds the tumor. Pancreatic stellate cells (PSCs) are thought to be responsible for …