GRPr Theranostics: current status of imaging and therapy using GRPr targeting radiopharmaceuticals

J Kurth, M Potratz, M Heuschkel… - Nuklearmedizin …, 2022 - thieme-connect.com
Addressing molecular targets, that are overexpressed by various tumor entities, using
radiolabeled molecules for a combined diagnostic and therapeutic (theranostic) approach is …

Gastrin-releasing peptide receptor agonists and antagonists for molecular imaging of breast and prostate cancer: from pre-clinical studies to translational perspectives

J Gorica, MS De Feo, L Filippi… - Expert Review of …, 2022 - Taylor & Francis
Introduction Prostate and breast cancer represent a leading cause of cancer-related death
worldwide with a dramatic social and demographic impact. Gastrin-releasing peptide …

An update of radiolabeled bombesin analogs for gastrin-releasing peptide receptor targeting

Z Yu, HJK Ananias, G Carlucci… - Current …, 2013 - ingentaconnect.com
Prostate cancer is a critical public health problem in USA and Europe. New non-invasive
imaging methods are urgently needed, due to the low accuracy and specificity of current …

Comparison of biological properties of [177Lu]Lu‐ProBOMB1 and [177Lu]Lu‐NeoBOMB1 for GRPR targeting

E Rousseau, J Lau, Z Zhang, C Zhang… - Journal of Labelled …, 2020 - Wiley Online Library
The gastrin‐releasing peptide receptor (GRPR) is overexpressed in prostate cancer and
other solid malignancies. Following up on our work on [68Ga] Ga‐ProBOMB1 that had better …

Phase I Trial of [99mTc]Tc-maSSS-PEG2-RM26, a Bombesin Analogue Antagonistic to Gastrin-Releasing Peptide Receptors (GRPRs), for SPECT Imaging of GRPR …

V Chernov, A Rybina, R Zelchan, A Medvedeva… - Cancers, 2023 - mdpi.com
Simple Summary Prostate and breast cancers are the most common malignancies. Accurate
diagnosis and staging of diseases are important for the prognosis and determination of …

Prostate cancer theranostics targeting gastrin-releasing peptide receptors

L Baratto, H Jadvar, A Iagaru - Molecular imaging and biology, 2018 - Springer
Gastrin-releasing peptide receptors (GRPRs), part of the bombesin (BBN) family, are
aberrantly overexpressed in many cancers, including those of the breast, prostate, pancreas …

Nuclear imaging of prostate cancer with gastrin-releasing-peptide-receptor targeted radiopharmaceuticals

HJK Ananias, IJ De Jong, RA Dierckx… - Current …, 2008 - ingentaconnect.com
Prostate cancer is one of the most common causes of cancer in men. Evaluating the different
stages of prostate cancer with conventional imaging techniques still proves difficult. Nuclear …

A radiotracer for molecular imaging and therapy of gastrin-releasing peptide receptor–positive prostate cancer

IJ Bratanovic, C Zhang, Z Zhang, HT Kuo… - Journal of Nuclear …, 2022 - Soc Nuclear Med
The gastrin-releasing peptide receptor (GRPR) is overexpressed in many solid
malignancies, particularly in prostate and breast cancers, among others. We synthesized …

Radiolabeled bombesin analogs

R Mansi, BA Nock, SU Dalm, MB Busstra… - Cancers, 2021 - mdpi.com
Simple Summary Recent medical advancements have strived for a personalized medicine
approach to patients, aimed at optimizing therapy outcomes with minimum toxicity. In this …

Lutetium-177 labeled bombesin peptides for radionuclide therapy

T Stott Reynolds, RP Bandari, Z Jiang… - Current …, 2016 - ingentaconnect.com
The rare-earth radionuclides that decay by beta particle (β-&) emission are considered to be
ideal in the context of targeted radiotherapy. The rare-earth isotopes exist primarily in the 3+ …