A major goal of cancer genomics is to identify all genes that play critical roles in
carcinogenesis. Most approaches focused on genes positively selected for mutations that …

Oncogenes and tumor suppressor genes (hereafter referred to as “cancer genes”) result in
cancer when they experience substitutions that prevent or distort their normal function. We …

Cancer develops as a result of somatic mutation and clonal selection, but quantitative
measures of selection in cancer evolution are lacking. We adapted methods from molecular …

The somatic landscape of the cancer genome results from different mutational processes
represented by distinct “mutational signatures.” Although several mutagenic mechanisms …

Background Carcinogenesis typically involves multiple somatic mutations in caretaker (DNA
repair) and gatekeeper (tumor suppressors and oncogenes) genes. Analysis of mutation …

Background Somatic mutations in cancer cells affect various genomic elements disrupting
important cell functions. In particular, mutations in DNA binding sites recognized by …

Cancer is a disease driven by both somatic mutations that increase survival and proliferation
of cell lineages and the evolution of genes associated with cancer risk in populations …

Background Cancer is characterized by both a high mutation rate as well as high rates of
cell division and cell death. We postulate that these conditions will result in the eventual …

Cancer driver genes can undergo positive selection for various types of genetic alterations,
including gain-of-function or loss-of-function mutations and copy number alterations (CNA) …

Distinguishing the driver mutations from somatic mutations in a tumor genome is one of the
major challenges of cancer research. This challenge is more acute and far from solved for …