Using meta-analyses, we introduce a unicellular attractor (UCA) model integrating essential
features of the 'atavistic reversal','cancer attractor','somatic mutation','genome chaos', and …

The main contradiction of multicellularity (MCM) is between the unicellular (UC) and
multicellular (MC) levels. In human interactome we revealed two giant clusters with MC and …

Cancer research has traditionally focused on the characterization of individual molecular
mechanisms that can contribute to cancer. Due to the multiple levels of genomic and non …

When discussing chromosomal instability, most of the literature focuses on the
characterization of individual molecular mechanisms. These studies search for genomic and …

Cancer is globally increasing. Since 2010 it has risen in incidence by 26.3%, with mortality
growing by 20.9% and cancer-associated invalidity increasing by 16.0%[1], painfully …

Cancer is caused by the accumulation of genetic alterations and therefore has been
historically considered to be irreversible. Intriguingly, several studies have reported that …

The purpose of our studies is to elucidate the nature of massive control of the whole genome
expression with a particular emphasis on cell-fate change. The whole genome expression is …

Cancer presents a serious threat to human health. The understanding of the cell fate
determination during development and tumor-genesis remains challenging in current cancer …

Background In the past 15 years, impressive progress has been made to understand the
molecular mechanism behind aneuploidy, largely due to the effort of using various-omics …

Cancer is traditionally labeled a “cellular growth problem.” However, it is fundamentally an
issue of macroevolution where new systems emerge from tissue by breaking various …