The importance of chemokines in alcoholic liver injury has been implicated. The role of the
chemokine, monocyte chemoattractant protein‐1 (MCP‐1), elevated in patients with …

This study tested the hypothesis that prolonged consumption of alcohol directly or indirectly,
through endotoxin influx in the circulation, stimulates the Kupffer cells to produce …

Kupffer cell and macrophage (MØ) activation contributes to steatosis, inflammation, and
fibrosis in alcoholic liver disease (ALD). We found increased frequency of MØ, T cells, and …

Objective Monocyte chemoattractant protein-1 (MCP-1, CCL2), the primary ligand for
chemokine receptor C–C chemokine receptor 2 (CCR2), is increased in livers of patients …

BACKGROUND Alcoholic liver disease is associated with increased hepatic expression of
monocyte chemoattractant protein 1 (MCP-1) and macrophage inflammatory protein 1α (MIP …

The biological effects of monocyte chemoattractant protein (MCP) 1 are mediated by binding
to CC chemokine receptor (CCR) 2. In the present studies, we used CCR2 knockout …

Monocyte chemoattractant protein-1 is one of the major CC chemokines that has been
implicated in liver injury. The CC chemokine receptor, CCR2, has been identified as the …

Chemokines are implicated in the pathogenesis of alcoholic liver disease in humans and in
experimental models of alcohol intoxication. The major sources of these chemokines are …

Macrophage migration inhibitory factor (MIF), a multipotent protein that exhibits both cytokine
and chemotactic properties, is expressed by many cell types, including hepatocytes and …

Although previous studies reported the involvement of the TLR4-TRIF pathway in alcohol-
induced liver injury, the role of TLR2 and TLR9 signaling in alcohol-mediated neutrophil …