Microbial production of natural and non-natural flavonoids: pathway engineering, directed evolution and systems/synthetic biology

RP Pandey, P Parajuli, MAG Koffas, JK Sohng - Biotechnology advances, 2016 - Elsevier
In this review, we address recent advances made in pathway engineering, directed
evolution, and systems/synthetic biology approaches employed in the production and …

[HTML][HTML] Metabolic engineering of microorganisms for the production of flavonoids

H Sheng, X Sun, Y Yan, Q Yuan, J Wang… - … in bioengineering and …, 2020 - frontiersin.org
Flavonoids are a class of secondary metabolites found in plant and fungus. They have been
widely used in food, pharmaceutical, and nutraceutical industries owing to their significant …

[HTML][HTML] Metabolic engineering of microbial cell factories for biosynthesis of flavonoids: A review

H Lou, L Hu, H Lu, T Wei, Q Chen - Molecules, 2021 - mdpi.com
Flavonoids belong to a class of plant secondary metabolites that have a polyphenol
structure. Flavonoids show extensive biological activity, such as antioxidative, anti …

[HTML][HTML] Flavonoid production: current trends in plant metabolic engineering and de novo microbial production

H Tariq, S Asif, A Andleeb, C Hano, BH Abbasi - Metabolites, 2023 - mdpi.com
Flavonoids are secondary metabolites that represent a heterogeneous family of plant
polyphenolic compounds. Recent research has determined that the health benefits of fruits …

Microbial cell factories for the production of flavonoids–barriers and opportunities

H Li, Y Lyv, S Zhou, S Yu, J Zhou - Bioresource Technology, 2022 - Elsevier
Flavonoids are natural plant products with important nutritional value, health-promoting
benefits, and therapeutic potential. The use of microbial cell factories to generate flavonoids …

[HTML][HTML] Pathway enzyme engineering for flavonoid production in recombinant microbes

J Zha, X Wu, G Gong, MAG Koffas - Metabolic Engineering …, 2019 - Elsevier
Metabolic engineering of microbial strains for the production of flavonoids of industrial
interest has attracted great attention due to its promising advantages over traditional …

Bacterial biosynthesis of flavonoids: Overview, current biotechnology applications, challenges, and prospects

CO Okoye, H Jiang, Y Wu, X Li, L Gao… - Journal of Cellular …, 2023 - Wiley Online Library
Flavonoids are secondary metabolites present in plant organs and tissues. These natural
metabolites are the most prevalent and display a wide range of beneficial physiological …

Metabolic engineering of flavonoids in plants and microorganisms

Y Wang, S Chen, O Yu - Applied Microbiology and Biotechnology, 2011 - Springer
Over 9,000 flavonoid compounds have been found in various plants, comprising one of the
largest families of natural products. Flavonoids are an essential factor in plant interactions …

High efficient production of plant flavonoids by microbial cell factories: Challenges and opportunities

J Sun, W Sun, G Zhang, B Lv, C Li - Metabolic engineering, 2022 - Elsevier
Plant flavonoids are secondary metabolites containing a benzo-γ-pyrone structure, which
are widely present in plants and have a variety of physiological and pharmacological …

Microbial biotransformation of bioactive flavonoids

H Cao, X Chen, AR Jassbi, J Xiao - Biotechnology Advances, 2015 - Elsevier
The bioactive flavonoids are considered as the most important phytochemicals in food,
which exert a wide range of biological benefits for human being. Microbial biotransformation …