Scaffold diversity is a crucial feature of compound collections that has a huge impact on their
success in biological screenings. The synthesis of highly complex and diverse scaffolds …

A key challenge in chemical biology is the design and synthesis of compound libraries
spanning large tracts of biologically relevant chemical space.[1–3] Libraries with high …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Small molecule modulators of biological function can be discovered by the screening of
compound libraries. However, it became apparent that some human disease related targets …

Which compound classes are best suited as probes and tools for chemical biology research
and as inspiration for medicinal chemistry programs? Chemical space is enormously large …

Mimicking nature synthetically: The successful development of multistep stereoselective
syntheses gives access to natural product inspired compound collections having carbo …

Selected natural products have long been considered as desirable targets for total synthesis
due to their unique biological properties and their challenging structural complexity …

Taking it easy: Natural product synthesis is a stressful task. Exploiting the understanding of
biosynthetic pathways and implementing genetic engineering into the synthetic chemist's …

During the last decade we have witnessed the emergence of combinatorial chemistry as a
tool for the discovery of new lead compounds.[1] Outstanding examples of sophisticated …

Natural products provide the inspiration for a variety of strategies used in the diversity-
oriented synthesis of novel small-molecule libraries. These libraries can be based on core …