[HTML][HTML] Healthy and osteoarthritis-affected joints facing the cellular crosstalk

S Semenistaja, S Skuja, A Kadisa, V Groma - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint
disease that is recognized as the most common type of arthritis. During the last decade, it …

[HTML][HTML] The role of inflammatory mediators and matrix metalloproteinases (MMPs) in the progression of osteoarthritis

A Mukherjee, B Das - Biomaterials and Biosystems, 2024 - Elsevier
Osteoarthritis (OA) is a chronic musculoskeletal disorder characterized by an imbalance
between (synthesis) and catabolism (degradation) in altered homeostasis of articular …

Synovium and the innate inflammatory network in osteoarthritis progression

R Liu-Bryan - Current rheumatology reports, 2013 - Springer
This review focuses on the recent advancements in the understanding of innate immunity in
the pathogenesis of osteoarthritis, particularly with attention to the roles of damage …

Role of inflammation and the immune system in the progression of osteoarthritis

JE Woodell‐May… - Journal of Orthopaedic …, 2020 - Wiley Online Library
Understanding the molecular drivers and feedback loops of osteoarthritis (OA) may provide
future therapeutic strategies to modulate the disease progression. The current paradigm of …

Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis

Y Wei, L Bai - Connective tissue research, 2016 - Taylor & Francis
Osteoarthritis (OA), the most common form of degenerative joint disease, is linked to high
morbidity. It is predicted to be the single greatest cause of disability in the general population …

Osteoarthritis: trauma vs disease

G Jiménez, J Cobo-Molinos, C Antich… - … , Current Strategies, and …, 2018 - Springer
Osteoarthritis (OA) is the most prevalent joint disease characterized by pain and
degenerative lesions of the cartilage, subchondral bone, and other joint tissues. The causes …

[HTML][HTML] Current concepts in the pathogenesis of osteoarthritis

S Krasnokutsky, M Attur, G Palmer, J Samuels… - Osteoarthritis and …, 2008 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease that progressively causes loss of joint
function and is the leading source of physical disability and impaired quality of life in …

Role of crosstalk between synovial cells and chondrocytes in osteoarthritis

B Chen, Y Sun, G Xu, J Jiang… - Experimental and …, 2024 - spandidos-publications.com
Osteoarthritis (OA) is a low‑grade, nonspecific inflammatory disease that affects the entire
joint. This condition is characterized by synovitis, cartilage erosion, subchondral bone …

[HTML][HTML] Insights on molecular mechanisms of chondrocytes death in osteoarthritis

E Charlier, B Relic, C Deroyer, O Malaise… - International journal of …, 2016 - mdpi.com
Osteoarthritis (OA) is a joint pathology characterized by progressive cartilage degradation.
Medical care is mainly based on alleviating pain symptoms. Compelling studies report the …

Cellular and molecular pathways of structural damage in rheumatoid arthritis

U Harre, G Schett - Seminars in immunopathology, 2017 - Springer
Structural damage of cartilage and bone tissue is a hallmark of rheumatoid arthritis (RA).
The resulting joint destruction constitutes one of the major disease consequences for …