Astrocytes in post-stroke depression: roles in inflammation, neurotransmission, and neurotrophin signaling

D Jing, X Hou, X Guo, X Zhao, K Zhang… - Cellular and Molecular …, 2023 - Springer
Post-stroke depression (PSD) is a frequent and disabling complication of stroke that affects
up to one-third of stroke survivors. The pathophysiology of PSD involves multiple …

Astrocytes in depression and Alzheimer's disease

Y Liao, Q Xing, Q Li, J Zhang, R Pan, Z Yuan - Frontiers of medicine, 2021 - Springer
Astrocytes are an abundant subgroup of cells in the central nervous system (CNS) that play
a critical role in controlling neuronal circuits involved in emotion, learning, and memory. In …

Targeting astrocytes in major depression

L Peng, A Verkhratsky, L Gu, B Li - Expert review of …, 2015 - Taylor & Francis
Astrocytes represent a highly heterogeneous population of neural cells primarily responsible
for the homeostasis of the CNS. Astrocytes express multiple receptors for neurotransmitters …

Differential and paradoxical roles of new-generation antidepressants in primary astrocytic inflammation

JH He, RP Liu, YM Peng, Q Guo, LB Zhu… - Journal of …, 2021 - Springer
Background Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine
reuptake inhibitors (SNRIs) are commonly used new-generation drugs for depression …

Astroglia abnormalities in post-stroke mood disorders

T Singer, S Ding, S Ding - Astrocytes in Psychiatric Disorders, 2021 - Springer
Stroke is the leading cause of human death and disability. After a stroke, many patients may
have some physical disability, including difficulties in moving, speaking, and seeing, but …

Astrocytes in stroke-induced neurodegeneration: a timeline

E Collyer, E Blanco-Suarez - Frontiers in Molecular Medicine, 2023 - frontiersin.org
Stroke is a condition characterized by sudden deprivation of blood flow to a brain region and
defined by different post-injury phases, which involve various molecular and cellular …

Regulation of neurotrophic factors and energy metabolism by antidepressants in astrocytes

JL Martin, PJ Magistretti, I Allaman - Current drug targets, 2013 - ingentaconnect.com
There is growing evidence that astrocytes are involved in the neuropathology of major
depression. In particular, decreases in glial cell density observed in the cerebral cortex of …

Astrocytes and gliotransmitters: new players in the treatment of major depression?

A Etiévant, L Lambás-Señas, H Scarna… - Current Drug …, 2013 - ingentaconnect.com
With a lifetime prevalence of more than 16% worldwide, major depressive disorder is one of
the most common psychiatric disorders. Only one third of patients experience a complete …

Astrocytes in post-traumatic stress disorder

B Li, D Zhang, A Verkhratsky - Neuroscience Bulletin, 2022 - Springer
Although posttraumatic stress disorder (PTSD) is on the rise, traumatic events and their
consequences are often hidden or minimized by patients for reasons linked to PTSD itself …

Unveiling the hidden pathways: Exploring astrocytes as a key target for depression therapy

Y Liu, L Chen, L Lin, C Xu, Y Xiong, H Qiu, X Li… - Journal of Psychiatric …, 2024 - Elsevier
Depressive disorders are widely debilitating psychiatric disease. Despite the considerable
progress in the field of depression therapy, extensive research spanning many decades has …