Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …

The transport of calcium ions (Ca 2+) to the cytosol is essential for immunoreceptor
signaling, regulating lymphocyte differentiation, activation, and effector function. Increases in …

Elevation of intracellular free Ca2+ is one of the key triggering signals for T-cell activation by
antigen. A remarkable variety of Ca2+ signals in T cells, ranging from infrequent spikes to …

During T cell activation, the engagement of a T cell with an antigen-presenting cell (APC)
results in rapid cytoskeletal rearrangements and a dramatic increase of intracellular calcium …

T cells are an essential component of the immune system that provide antigen-specific acute
and long lasting immune responses to infections and tumors, ascertain the maintenance of …

Alterations in the cytosolic concentration of calcium ions (Ca2+) transmit information that is
crucial for the development and function of B cells. Cytosolic Ca2+ concentration is …

Dendritic cells (DCs) are highly versatile antigen-presenting cells critically involved in both
innate and adaptive immunity as well as maintenance of self-tolerance. DC function is …

Calcium is the most abundant mineral in the human body and is central to many
physiological processes, including immune system activation and maintenance. Studies …

In T lymphocytes, calcium ion controls a variety of biological processes including
development, survival, proliferation, and effector functions. These distinct and specific roles …

Lymphocyte function is regulated by a network of ion channels and transporters in the
plasma membrane of B and T cells. These proteins modulate the cytoplasmic concentrations …