Background: Breast cancer is the most common cancer in women worldwide and although
mortality (129 000/year) stagnates, incidence (370 000/year) is increasing. In addition to …

Abstract Tpl-2/Cot proto-oncogene encodes a serine threonine kinase and was initially
cloned as a provirus insertion site in MoMuLV-induced T cell lymphomas in rats. Tpl-2 locus …

Although it is well established that some protein tyrosine kinases have a prognostic value in
breast cancer, the involvement of protein tyrosine phosphatases (PTPs) is poorly …

Objective: COX-2 is implicated in carcinogenesis and tumour progression in many cancers,
including breast cancer. Recently, it has been reported that human breast carcinomas …

Objectives: Cyclooxygenase (COX) is the rate-limiting enzyme that catalyzes the conversion
of arachidonic acid to prostaglandins. The purpose of the present study was to investigate …

Abstract Cyclooxygenase (COX)—2, an inducible isoform of cyclooxygenases, regulates the
rapid production of high levels of prostaglandins during inflammation. Cyclooxygenase-2 is …

Background and aim: The production of prostaglandins is regulated by cyclo-oxygenases
(COXs), which also have a role in tumour development and progression in various …

Tumor progression locus 2 (Tpl2) is a mitogen-activated protein kinase (MAPK) kinase
kinase (MAP3K) that conveys various intra-and extra-cellular stimuli to effector proteins of …

In order to investigate the implications of cyclooxygenase-2 (COX-2) expression in
combination with Ki-67 on breast cancer outcomes, the COX-2 and Ki-67 expression levels …

COX2 expression correlates with high-grade breast cancer, but the clinical significance and
possible prognostic influence in these patients have not been studied in depth. Our goal was …