Severe malaria due to Plasmodium falciparum infection causes nearly half a million deaths
per year. The different symptomatology and disease manifestations among patients have …

Cytoadhesion of P lasmodium falciparum‐infected erythrocytes to endothelial protein C
receptor (EPCR) is associated with severe malaria. It has been postulated that parasite …

Severe malaria manifests as several overlapping syndromes with high mortality. Interaction
of parasites with endothelial protein C receptors and high parasite biomass have recently …

P lasmodium falciparum‐infected erythrocytes (IRBC) expressing the domain cassettes (DC)
8 and 13 of the cytoadherent ligand P. falciparum erythrocyte membrane protein 1 adhere to …

Severe Plasmodium falciparum malaria infections are caused by microvascular
sequestration of parasites binding to the human endothelial protein C receptor (EPCR) via …

The interplay between cellular and molecular determinants that lead to severe malaria in
adults is unexplored. Here, we analyzed parasite virulence factors in an infected adult …

Of the five Plasmodium species that infect humans, infection with P. falciparum is the most
lethal, causing severe malaria syndromes, that result in over half a million annual deaths …

Sequestration of Plasmodium falciparum-infected erythrocytes in host blood vessels is a key
triggering event in the pathogenesis of severe childhood malaria, which is responsible for …

Of all the outcomes of Plasmodium falciparum infection, the coma of cerebral malaria (CM) is
particularly deadly. Malariologists have long wondered how some patients develop this …

Recent advances have identified a new paradigm for cerebral malaria pathogenesis in
which endothelial protein C receptor (EPCR) is a major host receptor for sequestration of …