Plant terpene specialized metabolism: complex networks or simple linear pathways?

ER Lanier, TB Andersen, B Hamberger - The Plant Journal, 2023 - Wiley Online Library
From the perspectives of pathway evolution, discovery and engineering of plant specialized
metabolism, the nature of the biosynthetic routes represents a critical aspect. Classical …

[HTML][HTML] P450s controlling metabolic bifurcations in plant terpene specialized metabolism

A Banerjee, B Hamberger - Phytochemistry Reviews, 2018 - Springer
Catalyzing stereo-and regio-specific oxidation of inert hydrocarbon backbones, and a range
of more exotic reactions inherently difficult in formal chemical synthesis, cytochromes P450 …

[HTML][HTML] Another level of complex-ity: The role of metabolic channeling and metabolons in plant terpenoid metabolism

M Gutensohn, E Hartzell, N Dudareva - Frontiers in Plant Science, 2022 - frontiersin.org
Terpenoids constitute one of the largest and most diverse classes of plant metabolites. While
some terpenoids are involved in essential plant processes such as photosynthesis …

Gene discovery of modular diterpene metabolism in nonmodel systems

P Zerbe, B Hamberger, MMS Yuen, A Chiang… - Plant …, 2013 - academic.oup.com
Plants produce over 10,000 different diterpenes of specialized (secondary) metabolism, and
fewer diterpenes of general (primary) metabolism. Specialized diterpenes may have …

[HTML][HTML] Evolutionary diversification of primary metabolism and its contribution to plant chemical diversity

HA Maeda - Frontiers in Plant Science, 2019 - frontiersin.org
Plants produce a diverse array of lineage-specific specialized (secondary) metabolites,
which are synthesized from primary metabolites. Plant specialized metabolites play crucial …

Making new molecules–evolution of pathways for novel metabolites in plants

DJ Kliebenstein, A Osbourn - Current opinion in plant biology, 2012 - Elsevier
Plants have adapted to their environments by diversifying in various ways. This
diversification is reflected at the phytochemical level in their production of numerous …

[HTML][HTML] Metabolic perturbation and synthetic biology strategies for plant terpenoid production—An updated overview

V Mani, S Park, JA Kim, SI Lee, K Lee - Plants, 2021 - mdpi.com
Terpenoids represent one of the high-value groups of specialized metabolites with vast
structural diversity. They exhibit versatile human benefits and have been successfully …

Something old, something new: conserved enzymes and the evolution of novelty in plant specialized metabolism

GD Moghe, RL Last - Plant Physiology, 2015 - academic.oup.com
Plants produce hundreds of thousands of small molecules known as specialized
metabolites, many of which are of economic and ecological importance. This remarkable …

Natural products–modifying metabolite pathways in plants

A Staniek, H Bouwmeester, PD Fraser… - Biotechnology …, 2013 - Wiley Online Library
The diversity of plant natural product (PNP) molecular structures is reflected in the variety of
biochemical and genetic pathways that lead to their formation and accumulation. Plant …

Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro

T Moses, J Pollier, JM Thevelein… - New Phytologist, 2013 - Wiley Online Library
Terpenoids constitute a large and diverse class of natural products that serve many
functions in nature. Most of the tens of thousands of the discovered terpenoids are …