STUDY QUESTION Can label-free, non-invasive optical imaging by hyperspectral
autofluorescence microscopy discern between euploid and aneuploid cells within the inner …

Purpose: Our purpose was to evaluate the utility of spectral imaging for multicolor,
multichromosome enumeration in human interphase cell nuclei. Methods: Chromosome …

Formation of a totipotent blastocyst capable of implantation is one of the first major
milestones in early mammalian embryogenesis, but less than half of in vitro fertilized …

Most human pre-implantation embryos are mosaics of euploid and aneuploid cells. To
determine the fate of aneuploid cells and the developmental potential of mosaic embryos …

Proper preimplantation development is essential to assemble a blastocyst capable of
implantation. Live imaging has uncovered major events driving early development in mouse …

Fluorescent live imaging of cells and embryos at subcellular resolution poses significant
challenges for biologists due to morbidity and mortality ensuing from phototoxicity. Here we …

Oocyte quality is a key factor influencing IVF success. The oocyte and surrounding cumulus
cells, known collectively as the cumulus oocyte complex (COC), communicate bi …

Only 30% of embryos from in vitro fertilized oocytes successfully implant and develop to
term, leading to repeated transfer cycles. To reduce time-to-pregnancy and stress for …

Cells of the early developing mammalian embryo frequently mis-segregate chromosomes
during cell division, causing daughter cells to inherit an erroneous numbers of …

A significant proportion of human preimplantation embryos produced during the course of in
vitro fertilization (IVF) treatments contain two or more cytogenetically distinct cell lines. This …