Reduced responsiveness to the anti-inflammatory effects of corticosteroids is a major barrier
to effective management of asthma in smokers and patients with severe asthma and in the …

Glucocorticoid insensitivity presents a profound management problem in patients with
asthma because conventional therapies are not effective. Glucocorticoids, acting through the …

Most patients with asthma are successfully treated with conventional therapy. Nevertheless,
there is a small proportion of asthmatic patients, including present cigarette smokers and …

Glucocorticoids are the mainstay of asthma management and effectively treat acute
exacerbations of asthma. However, a small subset of asthmatics, usually with severe …

Corticosteroids are the most potent anti-inflammatory agents used to treat chronic
inflammatory diseases such as bronchial asthma. However, there are a small number (, 5%) …

Glucocorticosteroids are the first-line therapy for controlling airway inflammation in asthma.
They bind intracellular glucocorticoid receptors to trigger increased expression of anti …

Resistance to the anti-inflammatory effects of glucocorticoids in asthma and other
inflammatory and immune diseases is uncommon, but presents a management problem …

Resistance to the antiinflammatory effects of corticosteroids is very uncommon in asthma but
common in chronic obstructive pulmonary disease. Recent understanding of the molecular …

Extensive development of inhaled and oral glucocorticoids has resulted in highly potent
molecules that have been optimized to target activity to the lung and minimize systemic …

Asthma is a common medical condition affecting 300 million people worldwide. Airway
inflammation, smooth muscle bronchoconstriction leading to airflow obstruction, and mucous …