The bioisosteres of 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles are well-known
pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1, 3, 4 …

Although studies in drug discovery have gained momentum in recent years, the conversion
of drugs in use today into less toxic derivatives with pharmacologically superior properties is …

Two series of amino-substituted 1, 2, 4-and 1, 3, 4-oxadiazole matched compounds were
evaluated and found to have significant differences in their various physical and …

The 5-membered oxadiazole and thiadiazole scaffolds are the most privileged and well-
known heterocycles, being a common and essential feature of a variety of natural products …

Two series of 2-substituted aryl, heteroaryl and alkyl, 4-substituted aryl 1, 3-oxazole (2a-k)
and thiazole (4a-k) molecular scaffolds containing divalent bioisosteres, viz., oxygen and …

1, 3, 4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …

1, 3, 4-oxadiazole, a privileged structure, endows its derivatives with broad and potent
biological functions, especially in antiviral activities, including anti-HIV, anti-HCV, anti-HBV …

Highlights•Triazoles mimic different functional groups, resulting optimal bioisosteres for the
synthesis of new active molecules.•Triazoles present a marked stability under hydrolytic …

Nitrogen heterocycles play an essential role in medication development. The 1, 2, 4‐
oxadiazole heterocycle has been extensively studied, yielding a large variety of molecules …

Oxadiazoles and thiadiazoles are malleable heterocycles that have recently generated
major interest in the field of medicinal chemistry. Compounds based on these moieties have …