Treatment of transplant kidneys during machine perfusion

SA Hosgood, M Hoff, ML Nicholson - Transplant International, 2021 - Wiley Online Library
The increasing use of donation after circulatory death (DCD) and extended criteria donor
(ECD) organs has raised awareness of the need to improve the quality of kidneys for …

Machine perfusion in kidney transplantation

A Kataria, S Magoon, B Makkar… - Current opinion in organ …, 2019 - journals.lww.com
Despite reduction in the rates of DGF by HMP, its effect on long-term renal and patient
outcomes is not clearly known. There is limited clinical literature in the use of normothermic …

Hypothermic machine perfusion in kidney transplantation

J De Deken, P Kocabayoglu… - Current opinion in organ …, 2016 - journals.lww.com
HMP has proven to be beneficial as a kidney preservation method for all types of renal
grafts, most notably those retrieved from extended criteria donors. Large numbers of …

Ex-vivo Kidney Machine Perfusion: Therapeutic Potential

R Zulpaite, P Miknevicius, B Leber, K Strupas… - Frontiers in …, 2021 - frontiersin.org
Kidney transplantation remains the gold standard treatment for patients suffering from end-
stage kidney disease. To meet the constantly growing organ demands grafts donated after …

Outcomes of kidney perfusion techniques in transplantation from deceased donors: a systematic review and meta-analysis

AS Ghoneima, RX Sousa Da Silva, MA Gosteli… - Journal of Clinical …, 2023 - mdpi.com
The high demand for organs in kidney transplantation and the expansion of the donor pool
have led to the widespread implementation of machine perfusion technologies. In this study …

Renal delivery of pharmacologic agents during machine perfusion to prevent ischaemia-reperfusion injury: from murine model to clinical trials

R Franzin, A Stasi, M Fiorentino, S Simone… - Frontiers in …, 2021 - frontiersin.org
Donor organ shortage still remains a serious obstacle for the access of wait-list patients to
kidney transplantation, the best treatment for End-Stage Kidney Disease (ESKD). To expand …

One‐year results of a prospective, randomized trial comparing two machine perfusion devices used for kidney preservation

M Wszola, A Kwiatkowski, P Diuwe… - Transplant …, 2013 - Wiley Online Library
Studies have shown beneficial effects of machine perfusion (MP) on early kidney function
and long‐term graft survival. The aim of this study was to investigate whether the type of …

Ex vivo machine perfusion for renal graft preservation

JM Kaths, A Paul, LA Robinson, M Selzner - Transplantation Reviews, 2018 - Elsevier
Kidney transplantation is the treatment of choice for end-stage renal disease. Despite its
superiority over dialysis, the persisting organ shortage remains a major drawback …

Mesenchymal stromal cells as anti-inflammatory and regenerative mediators for donor kidneys during normothermic machine perfusion

JM Sierra-Parraga, M Eijken, J Hunter… - Stem cells and …, 2017 - liebertpub.com
There is great demand for transplant kidneys for the treatment of end-stage kidney disease
patients. To expand the donor pool, organs from older and comorbid brain death donors, so …

Maximizing kidneys for transplantation using machine perfusion: from the past to the future: A comprehensive systematic review and meta-analysis

AM Hameed, HC Pleass, G Wong, WJ Hawthorne - Medicine, 2016 - journals.lww.com
Background: The two main options for renal allograft preservation are static cold storage
(CS) and machine perfusion (MP). There has been considerably increased interest in MP …