Chronic kidney disease (CKD)–mineral and bone disorder is associated with diverse
metabolic and endocrine disturbances that ultimately may contribute to further loss of kidney …

New advances in the pathogenesis of renal osteodystrophy (ROD) change the perspective
from which many of its features and treatment are viewed. Calcium, phosphate, parathyroid …

Intracellular phosphate is critical for cellular processes such as signaling, nucleic acid
synthesis, and membrane function. Extracellular phosphate (Pi) is an important component …

Maintenance of a normal serum phosphate level depends on absorption in the gut,
reabsorption and excretion by the kidney, and the flux between the extracellular and skeletal …

Chronic kidney disease mineral bone disorder (CKD-MBD) is a common co-morbidity in
patients with CKD. Characterized by laboratory abnormalities, bone abnormality, and …

Maintenance of phosphate balance is essential for life, and mammals have developed a
sophisticated system to regulate phosphate homeostasis over the course of evolution …

The importance of phosphate homeostasis in chronic kidney disease (CKD) has been
recognized for decades, but novel insights—which are frequently relevant to everyday …

Hyperphosphatemia is a common complication in patients with chronic kidney disease
(CKD), particularly in those requiring renal replacement therapy. The importance of …

For more than forty years now, high serum phosphate levels, a highly prevalent condition in
patients with chronic kidney disease (CKD), have been associated with the pathogenesis of …

High serum phosphate is linked to poor health outcome and mortality in chronic kidney
disease (CKD) patients before or after the initiation of dialysis. Therefore, maintenance of …