[HTML][HTML] Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription
Metrics commonly used to describe antibiotic efficacy rely on measurements performed on
bacterial populations. However, certain cells in a bacterial population can continue to grow …
bacterial populations. However, certain cells in a bacterial population can continue to grow …
Analysing the fitness cost of antibiotic resistance to identify targets for combination antimicrobials
A Rasouly, Y Shamovsky, V Epshtein, K Tam… - Nature …, 2021 - nature.com
Mutations in the rifampicin (Rif)-binding site of RNA polymerase (RNAP) confer antibiotic
resistance and often have global effects on transcription that compromise fitness and stress …
resistance and often have global effects on transcription that compromise fitness and stress …
Linking system-wide impacts of RNA polymerase mutations to the fitness cost of rifampin resistance in Pseudomonas aeruginosa
Q Qi, GM Preston, RC MacLean - MBio, 2014 - Am Soc Microbiol
Fitness costs play a key role in the evolutionary dynamics of antibiotic resistance in bacteria
by generating selection against resistance in the absence of antibiotics. Although the …
by generating selection against resistance in the absence of antibiotics. Although the …
Mutations in rpoB That Confer Rifampicin Resistance Can Alter Levels of Peptidoglycan Precursors and Affect β-Lactam Susceptibility
Bacteria can adapt to stressful conditions through mutations affecting the RNA polymerase
core subunits that lead to beneficial changes in transcription. In response to selection with …
core subunits that lead to beneficial changes in transcription. In response to selection with …
The impact of drug resistance on Mycobacterium tuberculosis physiology: what can we learn from rifampicin?
The emergence of drug-resistant pathogens poses a major threat to public health. Although
influenced by multiple factors, high-level resistance is often associated with mutations in …
influenced by multiple factors, high-level resistance is often associated with mutations in …
Epistasis between antibiotic resistance mutations and genetic background shape the fitness effect of resistance across species of Pseudomonas
T Vogwill, M Kojadinovic… - Proceedings of the …, 2016 - royalsocietypublishing.org
Antibiotic resistance often evolves by mutations at conserved sites in essential genes,
resulting in parallel molecular evolution between divergent bacterial strains and species …
resulting in parallel molecular evolution between divergent bacterial strains and species …
[HTML][HTML] A temporal proteome dynamics study reveals the molecular basis of induced phenotypic resistance in Mycobacterium smegmatis at sub-lethal rifampicin …
In the last 40 years only one new antitubercular drug has been approved, whilst resistance
to current drugs, including rifampicin, is spreading. Here, we used the model organism …
to current drugs, including rifampicin, is spreading. Here, we used the model organism …
[HTML][HTML] Antibiotic tolerance is associated with a broad and complex transcriptional response in E. coli
Antibiotic treatment kills a large portion of a population, while a small, tolerant subpopulation
survives. Tolerant bacteria disrupt antibiotic efficacy and increase the likelihood that a …
survives. Tolerant bacteria disrupt antibiotic efficacy and increase the likelihood that a …
[HTML][HTML] A trimethoprim derivative impedes antibiotic resistance evolution
MS Manna, YT Tamer, I Gaszek, N Poulides… - Nature …, 2021 - nature.com
The antibiotic trimethoprim (TMP) is used to treat a variety of Escherichia coli infections, but
its efficacy is limited by the rapid emergence of TMP-resistant bacteria. Previous laboratory …
its efficacy is limited by the rapid emergence of TMP-resistant bacteria. Previous laboratory …
Temporal and intrinsic factors of rifampicin tolerance in mycobacteria
K Richardson, OT Bennion, S Tan… - Proceedings of the …, 2016 - National Acad Sciences
Mycobacteria grow and divide asymmetrically, creating variability in growth pole age, growth
properties, and antibiotic susceptibilities. Here, we investigate the importance of growth pole …
properties, and antibiotic susceptibilities. Here, we investigate the importance of growth pole …