Bee venom improves diabetic wound healing by protecting functional macrophages from apoptosis and enhancing Nrf2, Ang-1 and Tie-2 signaling

WN Hozzein, G Badr, BM Badr, A Allam… - Molecular …, 2018 - Elsevier
Impaired wound healing is a serious complication of diabetes that negatively affects the
patient's socioeconomic life. Multiple mechanisms contribute to impaired diabetic wound …

Bee venom accelerates wound healing in diabetic mice by suppressing activating transcription factor‐3 (ATF‐3) and inducible nitric oxide synthase (iNOS)‐mediated …

G Badr, WN Hozzein, BM Badr… - Journal of cellular …, 2016 - Wiley Online Library
Multiple mechanisms contribute to impaired diabetic wound healing including impaired
neovascularization and deficient endothelial progenitor cell (EPC) recruitment. Bee venom …

Propolis and bee venom in diabetic wounds; a potential approach that warrants clinical investigation

N Al-Waili, WN Hozzein, G Badr, A Al-Ghamdi… - African Journal of …, 2015 - ajol.info
Background: Wound healing in diabetes mellitus is a complex multi-stage process that
requires the proper function of multiple systems. The mechanisms of impaired wound …

[HTML][HTML] Bee venom in wound healing

A Kurek-Górecka, K Komosinska-Vassev… - Molecules, 2020 - mdpi.com
Bee venom (BV), also known as api-toxin, is widely used in the treatment of different
inflammatory diseases such as rheumatoid arthritis or multiple sclerosis. It is also known that …

Betulinic acid accelerates diabetic wound healing by modulating hyperglycemia-induced oxidative stress, inflammation and glucose intolerance

W Xie, W Hu, Z Huang, M Li, H Zhang, X Huang… - Burns & …, 2022 - academic.oup.com
Background Diabetes significantly delays wound healing through oxidative stress,
inflammation and impaired re-epithelialization that lead to defective regulation of the healing …

[HTML][HTML] Protective effects of bee venom against endotoxemia-related acute kidney injury in mice

JY Kim, SJ Lee, YI Maeng, J Leem, KK Park - Biology, 2020 - mdpi.com
Sepsis-associated acute kidney injury (AKI) is a leading cause of death in hospitalized
patients worldwide. Despite decades of effort, there is no effective treatment for preventing …

[HTML][HTML] Huangbai liniment accelerated wound healing by activating Nrf2 signaling in diabetes

J Zhang, R Zhou, C Xiang, Q Jia, H Wu… - Oxidative Medicine and …, 2020 - hindawi.com
As a serious complication of diabetes, nonhealing skin ulcer leads to high mortality and
disability in diabetic patients. However, limited therapy is available in managing diabetic …

[HTML][HTML] Systemic bee venom exerts anti‑arthritic and anti‑inflammatory properties in a rat model of arthritis

DM El‑Tedawy, MM Abd‑Alhaseeb… - Biomedical …, 2020 - spandidos-publications.com
Bee venom (BV) is widely used as a traditional China medicine to treat various conditions,
including rheumatoid arthritis (RA). The aim of the present study was to evaluate the effects …

Accelerated wound healing and anti-inflammatory effects of physically cross linked polyvinyl alcohol–chitosan hydrogel containing honey bee venom in diabetic rats

MA Amin, IT Abdel-Raheem - Archives of pharmacal research, 2014 - Springer
Diabetes is one of the leading causes of impaired wound healing. The objective of this study
was to develop a bee venom-loaded wound dressing with an enhanced healing and anti …

High-glucose environment enhanced oxidative stress and increased interleukin-8 secretion from keratinocytes: new insights into impaired diabetic wound healing

CCE Lan, CS Wu, SM Huang, IH Wu, GS Chen - Diabetes, 2013 - Am Diabetes Assoc
Impaired wound healing frequently occurs in patients with diabetes. Interleukin (IL)-8
production by keratinocyte is responsible for recruiting neutrophils during healing. Intense …