Simple Summary The pathogenesis of autoimmune diseases etiology is still mostly unclear
and probably arises from an interplay between common/rare genetic variants and …

In recent years, the physiological and molecular functions of vitamin D (Vit-D) have been
deeply investigated. At first, Vit-D was considered a regulator of mineral and skeletal …

IMAJ• VOL 19• JULY 2017 ulation of cellular growth, proliferation, apoptosis, and immune
cell activation [2]. Awareness of a the role vitamin D takes in the regulation of immune …

Vitamin D is an important hormone involved in various physiologic processes, and its activity
is linked to binding with vitamin D receptor (VDR). Genetic polymorphisms in the VDR gene …

Lately, vitamin D has been linked with metabolic and immunological processes, which
established its role as an essential component of human health preservation. Vitamin D has …

Over the last three decades, it has become clear that the role of vitamin D goes beyond the
regulation of calcium homeostasis and bone health. An important extraskeletal effect of …

Large numbers of statistically significant associations between sentinel SNPs and case-
control status have been replicated by genome-wide association studies. Nevertheless, few …

It has proven difficult to identify the underlying genes in complex autoimmune diseases.
Here, we use forward genetics to identify polymorphisms in the vitamin D receptor gene …

Vitamin D has a plethora of functions that are important for the maintenance of general
health and in particular, the functional integrity of the immune system, such as promoting an …

A high prevalence of vitamin D (calcidiol) serum deficiency has been described in several
autoimmune diseases, including multiple sclerosis (MS), rheumatoid arthritis (AR), and …